Evidence map›Paper›PMID 22647256›Full record

Trial reportJournal of Alzheimer's disease : JAD2012

Independent deficits of visual word and motion processing in aging and early Alzheimer's disease.

Carla Velarde, Elizabeth Perelstein, Wendy Ressmann, Charles J Duffy

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Carla VelardeDepartment of Neurology, University of Rochester Medical Center, Rochester, NY 14642-0673, USA.
Elizabeth Perelstein
Wendy Ressmann
Charles J Duffy
University of Rochester Medical Center · US

Funding

VISUAL MOTION PROCESSING DURING OBSERVER MOVEMENTR01EY010287 · NEI · UNIVERSITY OF ROCHESTER · PI DUFFY, CHARLES J · 1994 to 2009
$3.6M
PERCEPTUAL MECHANISMS OF VISUOSPATIAL ORIENTATIONR01AG017596 · NIA · UNIVERSITY OF ROCHESTER · PI DUFFY, CHARLES J · 2000 to 2010
$3.2M
Integrating Neurophysiological Views of the Aging Visual SystemR01EY022062 · NEI · UNIVERSITY OF ROCHESTER · PI DUFFY, CHARLES J · 2012 to 2016
$2.5M
VIRTUAL FORCE STIMULATION: MOTOR CONTROLP41RR009283 · NCRR · UNIVERSITY OF ROCHESTER · PI HAYHOE, MARY M · 1994 to 2001
$1.6M
Attention and Memory Influences on Navigation in Alzheimer's DiseaseK23AG020647 · NIA · UNIVERSITY OF ROCHESTER · PI MAPSTONE, MARK · 2003 to 2007
$565k
NCRR NIH HHS P41 RR009283NEI NIH HHS EY10287NEI NIH HHS R01 EY010287NEI NIH HHS R01 EY022062NIA NIH HHS AG17596NIA NIH HHS AG20647NIA NIH HHS K23 AG020647NIA NIH HHS R01 AG017596
6 · The paper itself

Abstract

We tested whether visual processing impairments in aging and Alzheimer's disease (AD) reflect uniform posterior cortical decline, or independent disorders of visual processing for reading and navigation. Young and older normal controls were compared to early AD patients using psychophysical measures of visual word and motion processing. We find elevated perceptual thresholds for letters and word discrimination from young normal controls, to older normal controls, to early AD patients. Across subject groups, visual motion processing showed a similar pattern of increasing thresholds, with the greatest impact on radial pattern motion perception. Combined analyses show that letter, word, and motion processing impairments are independent of each other. Aging and AD may be accompanied by independent impairments of visual processing for reading and navigation. This suggests separate underlying disorders and highlights the need for comprehensive evaluations to detect early deficits.

Indexed as

AgedAgingAlzheimer DiseaseDiscrimination LearningEarly DiagnosisFemaleHumansMaleMotion PerceptionNeuropsychological TestsPattern Recognition, VisualPhotic StimulationReadingYoung Adult

Identifiers

PMID22647256
PMCPMC3732794
OpenAlexW1590707177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.