ArticleACS nano2012
The fate of ZnO nanoparticles administered to human bronchial epithelial cells.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 159 citations in OpenAlex.
- Oral Exposure to Titanium Dioxide E171 and Zinc Oxide Nanoparticles Induces Multi-Organ Damage in Rats: Role of Ceramide.International journal of molecular sciences · 2024Article
- Influence of Dietary Biosynthesized Zinc Oxide Nanoparticles on Broiler Zinc Uptake, Bone Quality, and Antioxidative Status.Animals : an open access journal from MDPI · 2022Article
- Food Additive Zinc Oxide Nanoparticles: Dissolution, Interaction, Fate, Cytotoxicity, and Oral Toxicity.International journal of molecular sciences · 2022Review
- Cellular binding, uptake and biotransformation of silver nanoparticles in human T lymphocytes.Nature nanotechnology · 2021Article
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Role of inorganic nanoparticle degradation in cancer therapy.Nanoscale advances · 2020Review
- Doped Zinc Oxide Nanoparticles: Synthesis, Characterization and Potential Use in Nanomedicine.Applied sciences (Basel, Switzerland) · 2020Article
- Model-Based Nanoengineered Pharmacokinetics of Iron-Doped Copper Oxide for Nanomedical Applications.Angewandte Chemie (International ed. in English) · 2020Article
- Fate Determination of ZnO in Commercial Foods and Human Intestinal Cells.International journal of molecular sciences · 2020Article
- Article
- Inhalation of ZnO Nanoparticles: Splice Junction Expression and Alternative Splicing in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- ZnO Nanoparticles Induced Male Reproductive Toxicity Based on the Effects on the Endoplasmic Reticulum Stress Signaling Pathway.International journal of nanomedicine · 2019Article
- Antileishmanial activity and cytotoxicity of ZnO-based nano-formulations.International journal of nanomedicine · 2019Article
- Exploring multiple effects of ZnScientific reports · 2018Article
- Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes.Nanoscale research letters · 2018Review
- Article
- ZnO nanoparticle preparation route influences surface reactivity, dissolution and cytotoxicity.Environmental science. Nano · 2018Article
- Facilitation of trace metal uptake in cells by inulin coating of metallic nanoparticles.Royal Society open science · 2017Article
- Mapping differential cellular protein response of mouse alveolar epithelial cells to multi-walled carbon nanotubes as a function of atomic layer deposition coating.Nanotoxicology · 2017Article
- Complete transformation of ZnO and CuO nanoparticles in culture medium and lymphocyte cells during toxicity testing.Nanotoxicology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
A particular challenge for nanotoxicology is the evaluation of the biological fate and toxicity of nanomaterials that dissolve in aqueous fluids. Zinc oxide nanomaterials are of particular concern because dissolution leads to release of the toxic divalent zinc ion. Although zinc ions have been implicated in ZnO cytotoxicity, direct identification of the chemical form of zinc taken up by cells exposed to ZnO nanoparticles, and its intracellular fate, has not yet been achieved. We combined high resolution X-ray spectromicroscopy and high elemental sensitivity X-ray microprobe analyses to determine the fate of ZnO and less soluble iron-doped ZnO nanoparticles following exposure to cultures of human bronchial epithelial cells, BEAS-2B. We complemented two-dimensional X-ray imaging methods with atomic force microscopy of cell surfaces to distinguish between nanoparticles that were transported inside the cells from those that adhered to the cell exterior. The data suggest cellular uptake of ZnO nanoparticles is a mechanism of zinc accumulation in cells. Following uptake, ZnO nanoparticles dissolved completely generating intracellular Zn(2+) complexed by molecular ligands. These results corroborate a model for ZnO nanoparticle toxicity that is based on nanoparticle uptake followed by intracellular dissolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.