Evidence map›Paper›PMID 22646669›Full record

ArticleOrganic letters2012

HPLC-assisted automated oligosaccharide synthesis.

N Vijaya Ganesh, Kohki Fujikawa, Yih Horng Tan, Keith J Stine, Alexei V Demchenko

Abstract read
In one paragraph

Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Carbohydrate Synthesis is Entering the Data-Driven Digital Era.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  7. Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
  8. Review
  9. Article
  10. HPLC-Based Automated Synthesis and Purification of Carbohydrates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  11. Article
  12. VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes.Journal of the American Chemical Society · 2022
    Article
  13. Review
  14. HPLC-Based Automated Synthesis of Glycans in Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  15. Review
  16. Article
  17. Synthetic Carbohydrate Chemistry and Translational Medicine.The Journal of organic chemistry · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

N Vijaya GaneshDepartment of Chemistry and Biochemistry and the Center for Nanoscience, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA.
Kohki Fujikawa
Yih Horng Tan
Keith J Stine
Alexei V Demchenko

Funding

Development and Application of Surface-Tethered Iterative Carbohydrate SynthesisR01GM090254 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI STINE, KEITH J. · 2009 to 2012
$1.1M
New strategies for expeditious oligosaccharide synthesisR15GM077170 · NIGMS · UNIVERSITY OF MISSOURI-ST. LOUIS · PI DEMCHENKO, ALEXEI V · 2006 to 2011
$748k
NIGMS NIH HHS GM077170NIGMS NIH HHS GM090254NIGMS NIH HHS R01 GM090254NIGMS NIH HHS R15 GM077170
6 · The paper itself

Abstract

A standard HPLC was adapted to polymer supported oligosaccharide synthesis. Solution-based reagents are delivered using a software-controlled solvent delivery system. The reaction progress and completion can be monitored in real time using a standard UV detector. All steps of oligosaccharide assembly including loading, glycosylation, deprotection, and cleavage can be performed using this setup.

Indexed as

Automation, LaboratoryChromatography, High Pressure LiquidMolecular StructureOligosaccharidesPolymersSoftwareOligosaccharidesPolymers

Identifiers

PMID22646669
PMCPMC3426652

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.