ArticleBMC genomics2012
Limitations of the rhesus macaque draft genome assembly and annotation.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Novel Insights into the Landscape of Crossover and Noncrossover Events in Rhesus Macaques (Macaca mulatta).Genome biology and evolution · 2024Article
- Divergent sensory and immune gene evolution in sea turtles with contrasting demographic and life histories.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- GALA: a computational framework for de novo chromosome-by-chromosome assembly with long reads.Nature communications · 2023Article
- MicroRNA Signatures of the Developing Primate Fovea.Frontiers in cell and developmental biology · 2021Article
- Repertoire-wide gene structure analyses: a case study comparing automatically predicted and manually annotated gene models.BMC genomics · 2019Article
- The Whole-Genome Sequence of the Coral Acropora millepora.Genome biology and evolution · 2019Article
- Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism forFrontiers in microbiology · 2019Article
- Molecular Cytogenetic Analysis of One African and Five Asian Macaque Species Reveals Identical Karyotypes as in Mandrill.Current genomics · 2018Article
- Reconstruction and evolutionary history of eutherian chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Genomic Tools for the Use of Nonhuman Primates in Translational Research.ILAR journal · 2017Review
- Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration.Drug and alcohol dependence · 2017Article
- Similar Ratios of Introns to Intergenic Sequence across Animal Genomes.Genome biology and evolution · 2017Article
- Structure and Diversity of the Rhesus Macaque Immunoglobulin Loci through MultipleFrontiers in immunology · 2017Article
- Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas.Human molecular genetics · 2016Article
- Unraveling the message: insights into comparative genomics of the naked mole-rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Exome screening to identify loss-of-function mutations in the rhesus macaque for development of preclinical models of human disease.BMC genomics · 2016Article
- Article
- An update of the macaque testis proteome.Data in brief · 2015Article
- Identifying rhesus macaque gene orthologs using heterospecific human CNV probes.Genomics data · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Finished genome sequences and assemblies are available for only a few vertebrates. Thus, investigators studying many species must rely on draft genomes. Using the rhesus macaque as an example, we document the effects of sequencing errors, gaps in sequence and misassemblies on one automated gene model pipeline, Gnomon. The combination of draft genome with automated gene finding software can result in spurious sequences. We estimate that approximately 50% of the rhesus gene models are missing, incomplete or incorrect. The problems identified in this work likely apply to all draft vertebrate genomes annotated with any automated gene model pipeline and thus represent a pervasive challenge to the analysis of draft genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.