ReviewClinical & developmental immunology2012
Autoimmunity and extrahepatic manifestations in treatment-naïve children with chronic hepatitis C virus infection.
Review in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Viral hepatitis management in pregnancy: practical insights from a pediatric perspective.Translational gastroenterology and hepatology · 2024Article
- Adolescents with chronic hepatitis C might be good candidates for direct-acting antiviral therapy.Clinical case reports · 2022Article
- Cascade of care for children and adolescents with chronic hepatitis C.World journal of gastroenterology · 2021Review
- Hepatitis C in Pregnancy: A Unique Opportunity to Improve the Hepatitis C Cascade of Care.Hepatology communications · 2019Review
- Hepatitis C virus infection in mothers and children.Canadian liver journal · 2019Article
- Hepatitis C virus infection in children and adolescents.Hepatology communications · 2017Review
- Autoimmune Movement Disorders: a Clinical and Laboratory Approach.Current neurology and neuroscience reports · 2017Review
- Vertically acquired hepatitis C virus infection: Correlates of transmission and disease progression.World journal of gastroenterology · 2016Review
- Vertical transmission of hepatitis C: towards universal antenatal screening in the era of new direct acting antivirals (DAAs)? Short review and analysis of the situation in Switzerland.Journal of virus eradication · 2016Review
- Autoimmune reactions in the course of the hepatitis C virus (HCV) infection.Clinical and experimental hepatology · 2015Review
- Natural history of vertically acquired HCV infection and associated autoimmune phenomena.European journal of pediatrics · 2014Article
- Redox regulation of protein damage in plasma.Redox biology · 2014Review
- Complexities in the relationship between infection and autoimmunity.Current allergy and asthma reports · 2014Review
- Study of non-organ-specific antibodies in children with genotype 4 chronic hepatitis C.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults. Few data are available on these topics in children. Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children. Smooth muscle autoantibody is the most common autoantibody found, while liver-kidney microsomal type-1 antibody positivity is the most peculiar autoimmune feature of children with HCV infection. The clinical significance of non-organ specific autoantibodies in the course of paediatric chronic hepatitis C is still debated. Autoantibody positivity can be considered neutral for most patients, while it can be associated with negative connotations for others, especially those positive for liver-kidney microsomal type-1 autoantibody. Subclinical hypothyroidism but not autoimmune thyroiditis has been demonstrated in HCV infection in children, while only few cases of HCV-associated membranoproliferative glomerulonephritis have been described. Single reports are available in the literature reporting the anecdotal association between chronic hepatitis C and other extrahepatic manifestations such as myopathy and opsoclonus-myoclonus syndrome. Despite the low incidence of extrahepatic manifestations of chronic hepatitis C in children, overall, available data suggest a careful monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.