Evidence map›Paper›PMID 22645596›Full record

ArticleFrontiers in plant science2012

Endoplasmic reticulum-associated degradation of glycoproteins in plants.

Silvia Hüttner, Richard Strasser

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
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  7. Development ofFrontiers in genetics · 2022
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Heat shock proteins gene expression and physiological responses in durum wheat (Physiology and molecular biology of plants : an international journal of functional plant biology · 2020
    Article
  13. Article
  14. Cytosolic FreeFrontiers in plant science · 2020
    Article
  15. Article
  16. Article
  17. The glycan-dependent ERAD machinery degrades topologically diverse misfolded proteins.The Plant journal : for cell and molecular biology · 2018
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Silvia HüttnerDepartment of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna, Austria.
Richard Strasser
BOKU University · AT

Funding

Austrian Science Fund FWF P 20817
6 · The paper itself

Abstract

In all eukaryotes the endoplasmic reticulum (ER) has a central role in protein folding and maturation of secretory and membrane proteins. Upon translocation into the ER polypeptides are immediately subjected to folding and modifications involving the formation of disulfide bridges, assembly of subunits to multi-protein complexes, and glycosylation. During these processes incompletely folded, terminally misfolded, and unassembled proteins can accumulate which endanger the cellular homeostasis and subsequently the survival of cells and tissues. Consequently, organisms have developed a quality control system to cope with this problem and remove the unwanted protein load from the ER by a process collectively referred to as ER-associated degradation (ERAD) pathway. Recent studies in Arabidopsis have identified plant ERAD components involved in the degradation of aberrant proteins and evidence was provided for a specific role in abiotic stress tolerance. In this short review we discuss our current knowledge about this important cellular pathway.

Indexed as

endoplasmic reticulumprotein degradationprotein glycosylationprotein quality controlubiquitin–proteasome

Identifiers

PMID22645596
PMCPMC3355801
OpenAlexW2163967479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.