ArticleFrontiers in plant science2011
The use of natural genetic diversity in the understanding of metabolic organization and regulation.
Article in Frontiers in plant science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genome-wide association analysis and linkage mapping decipher the genetic control of primary metabolites and quality traits in Capsicum.The Plant journal : for cell and molecular biology · 2025Article
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- Natural variation of respiration-related traits in plants.Plant physiology · 2023Review
- Metabolite database for root, tuber, and banana crops to facilitate modern breeding in understudied crops.The Plant journal : for cell and molecular biology · 2020Article
- Fruit metabolic and transcriptional programs differentiate among Andean tomato (Solanum lycopersicum L.) accessions.Planta · 2019Article
- Multi-tissue integration of transcriptomic and specialized metabolite profiling provides tools for assessing the common bean (Phaseolus vulgaris) metabolome.The Plant journal : for cell and molecular biology · 2019Article
- Untargeted MetabotypingFrontiers in plant science · 2017Article
- Combined Use of Genome-Wide Association Data and Correlation Networks Unravels Key Regulators of Primary Metabolism in Arabidopsis thaliana.PLoS genetics · 2016Article
- Non-targeted Metabolomics in Diverse Sorghum Breeding Lines Indicates Primary and Secondary Metabolite Profiles Are Associated with Plant Biomass Accumulation and Photosynthesis.Frontiers in plant science · 2016Article
- Combining Quantitative Genetics Approaches with Regulatory Network Analysis to Dissect the Complex Metabolism of the Maize Kernel.Plant physiology · 2016Article
- Integrative Approaches to Enhance Understanding of Plant Metabolic Pathway Structure and Regulation.Plant physiology · 2015Article
- Identification of QTLs affecting scopolin and scopoletin biosynthesis in Arabidopsis thaliana.BMC plant biology · 2014Article
- Recent Advances in the Application of Metabolomics to Studies of Biogenic Volatile Organic Compounds (BVOC) Produced by Plant.Metabolites · 2014Review
- Metabolomics of forage plants: a review.Annals of botany · 2012Review
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The study of metabolic regulation has traditionally focused on analysis of specific enzymes, emphasizing kinetic properties, and the influence of protein interactions and post-translational modifications. More recently, reverse genetic approaches permit researchers to directly determine the effects of a deficiency or a surplus of a given enzyme on the biochemistry and physiology of a plant. Furthermore, in many model species, gene expression atlases that give important spatial information concerning the quantitative expression level of metabolism-associated genes are being produced. In parallel, "top-down" approaches to understand metabolic regulation have recently been instigated whereby broad genetic diversity is screened for metabolic traits and the genetic basis of this diversity is defined thereafter. In this article we will review recent examples of this latter approach both in the model species Arabidopsis thaliana and the crop species tomato (Solanum lycopersicum). In addition to highlighting examples in which this genetic diversity approach has proven promising, we will discuss the challenges associated with this approach and provide a perspective for its future utility.
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