ArticleProceedings of the National Academy of Sciences of the United States of America2012
Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Cell wall remodeling-dependent morphotype switch inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular epidemiology of clinicalFrontiers in microbiology · 2026Article
- Unveiling the Mechanisms of Bacterial Resistance and Countermeasures.Pathogens (Basel, Switzerland) · 2025Review
- The genus Akkermansia is populated by a multitude of biological species with a wide distribution in the animal kingdom.Biology direct · 2025Article
- The DigH glycosyl hydrolase is conditionally required for daughter cell separation inJournal of bacteriology · 2025Article
- Multidrug Resistance and Virulence Traits ofAntibiotics (Basel, Switzerland) · 2025Article
- Insertion sequence elements and unique symmetrical genomic regions mediate chromosomal inversions in Streptococcus pyogenes.Nucleic acids research · 2024Article
- Mobilome impacts on physiology in the widely used non-toxic mutant Microcystis aeruginosa PCC 7806 ΔmcyB and toxic wildtype.BMC genomics · 2024Article
- Experimental evolution ofmBio · 2024Article
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- Replication-associated inversions are the dominant form of bacterial chromosome structural variation.Life science alliance · 2023Article
- NewInternational journal of molecular sciences · 2022Article
- Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes.PLoS biology · 2022Article
- Genomic structural plasticity of rodent-associated Bartonella in nature.Molecular ecology · 2022Article
- Staphylococcus aureus utilizes environmental RNA as a building material in specific polysaccharide-dependent biofilms.NPJ biofilms and microbiomes · 2022Article
- Fatal affairs - conjugational transfer of a dinoflagellate-killing plasmid between marineMicrobial genomics · 2022Article
- Review
- Radical genome remodelling accompanied the emergence of a novel host-restricted bacterial pathogen.PLoS pathogens · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome inversions are ubiquitous in organisms ranging from prokaryotes to eukaryotes. Typical examples can be identified by comparing the genomes of two or more closely related organisms, where genome inversion footprints are clearly visible. Although the evolutionary implications of this phenomenon are huge, little is known about the function and biological meaning of this process. Here, we report our findings on a bacterium that generates a reversible, large-scale inversion of its chromosome (about half of its total genome) at high frequencies of up to once every four generations. This inversion switches on or off bacterial phenotypes, including colony morphology, antibiotic susceptibility, hemolytic activity, and expression of dozens of genes. Quantitative measurements and mathematical analyses indicate that this reversible switching is stochastic but self-organized so as to maintain two forms of stable cell populations (i.e., small colony variant, normal colony variant) as a bet-hedging strategy. Thus, this heritable and reversible genome fluctuation seems to govern the bacterial life cycle; it has a profound impact on the course and outcomes of bacterial infections.
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