ArticleGenome research2012
Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses.Nature communications · 2026Article
- Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.Molecular biology and evolution · 2025Article
- Stem cell transcriptional profiles from mouse subspecies reveal cis-regulatory evolution at translation genes.Heredity · 2024Article
- Article
- A computational investigation of cis-gene regulation in evolution.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Existing methods are effective at measuring natural selection on gene expression.Nature ecology & evolution · 2022Article
- Reply to: Existing methods are effective at measuring natural selection on gene expression.Nature ecology & evolution · 2022Article
- Article
- Lineage-specific selection and the evolution of virulence in theProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Large-Scale Genome Scanning within Exonic Regions Revealed the Contributions of Selective Sweep Prone Genes to Host Divergence and Adaptation inMicroorganisms · 2021Article
- Divergence of Peroxisome Membrane Gene Sequence and Expression Between Yeast Species.G3 (Bethesda, Md.) · 2020Article
- Transcriptional Heterogeneity ofmSphere · 2018Article
- Functional characterization of adaptive variation within a cis-regulatory element influencing Drosophila melanogaster growth.PLoS biology · 2018Article
- High-resolution mapping ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genetic basis of mycotoxin susceptibility differences between budding yeast isolates.Scientific reports · 2017Article
- Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids.Scientific reports · 2017Article
- Cis-Regulatory Divergence in Gene Expression between Two Thermally Divergent Yeast Species.Genome biology and evolution · 2017Article
- Exploiting budding yeast natural variation for industrial processes.Current genetics · 2016Review
- Population perspectives on functional genomic variation in yeast.Briefings in functional genomics · 2016Review
- Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
The acquisition of new genes, via horizontal transfer or gene duplication/diversification, has been the dominant mechanism thus far implicated in the evolution of microbial pathogenicity. In contrast, the role of many other modes of evolution--such as changes in gene expression regulation-remains unknown. A transition to a pathogenic lifestyle has recently taken place in some lineages of the budding yeast Saccharomyces cerevisiae. Here we identify a module of physically interacting proteins involved in endocytosis that has experienced selective sweeps for multiple cis-regulatory mutations that down-regulate gene expression levels in a pathogenic yeast. To test if these adaptations affect virulence, we created a panel of single-allele knockout strains whose hemizygous state mimics the genes' adaptive down-regulations, and measured their virulence in a mammalian host. Despite having no growth advantage in standard laboratory conditions, nearly all of the strains were more virulent than their wild-type progenitor, suggesting that these adaptations likely played a role in the evolution of pathogenicity. Furthermore, genetic variants at these loci were associated with clinical origin across 88 diverse yeast strains, suggesting the adaptations may have contributed to the virulence of a wide range of clinical isolates. We also detected pleiotropic effects of these adaptations on a wide range of morphological traits, which appear to have been mitigated by compensatory mutations at other loci. These results suggest that cis-regulatory adaptation can occur at the level of physically interacting modules and that one such polygenic adaptation led to increased virulence during the evolution of a pathogenic yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.