ArticleGenome research2012
Random X inactivation in the mule and horse placenta.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- X chromosome inactivation in mammals: general principles and species-specific considerations.EMBO reports · 2025Review
- Compensation of gene dosage on the mammalian X.Development (Cambridge, England) · 2024Review
- Machine learning on alignment features for parent-of-origin classification of simulated hybrid RNA-seq.BMC bioinformatics · 2024Article
- Epigenetic Reprogramming inCells · 2023Review
- X chromosome inactivation in the human placenta is patchy and distinct from adult tissues.HGG advances · 2022Article
- Genome collinearity analysis illuminates the evolution of donkey chromosome 1 and horse chromosome 5 in perissodactyls: A comparative study.BMC genomics · 2021Article
- X chromosome-dependent disruption of placental regulatory networks in hybrid dwarf hamsters.Genetics · 2021Article
- Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing.Epigenetics & chromatin · 2021Article
- No imprinted XIST expression in pigs: biallelic XIST expression in early embryos and random X inactivation in placentas.Cellular and molecular life sciences : CMLS · 2019Article
- Characterization of the placental transcriptome through mid to late gestation in the mare.PloS one · 2019Article
- The Role of Xist in X-Chromosome Dosage Compensation.Trends in cell biology · 2018Review
- Article
- Global assessment of imprinted gene expression in the bovine conceptus by next generation sequencing.Epigenetics · 2016Article
- Strong Constraint on Human Genes Escaping X-Inactivation Is Modulated by their Expression Level and Breadth in Both Sexes.Molecular biology and evolution · 2016Article
- Profiling of exercise-induced transcripts in the peripheral blood cells of Thoroughbred horses.Journal of equine science · 2016Article
- Sex-Specific Placental Responses in Fetal Development.Endocrinology · 2015Review
- A review of inter- and intraspecific variation in the eutherian placenta.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Paternal X inactivation does not correlate with X chromosome evolutionary strata in marsupials.BMC evolutionary biology · 2014Article
- Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers.BMC genomics · 2014Article
- Applied equine genetics.Equine veterinary journal · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eutherian mammals, dosage compensation of X-linked genes is achieved by X chromosome inactivation. X inactivation is random in embryonic and adult tissues, but imprinted X inactivation (paternal X silencing) has been identified in the extra-embryonic membranes of the mouse, rat, and cow. Few other species have been studied for this trait, and the data from studies of the human placenta have been discordant or inconclusive. Here, we quantify X inactivation using RNA sequencing of placental tissue from reciprocal hybrids of horse and donkey (mule and hinny). In placental tissue from the equid hybrids and the horse parent, the allelic expression pattern was consistent with random X inactivation, and imprinted X inactivation can clearly be excluded. We characterized horse and donkey XIST gene and demonstrated that XIST allelic expression in female hybrid placental and fetal tissues is negatively correlated with the other X-linked genes chromosome-wide, which is consistent with the XIST-mediated mechanism of X inactivation discovered previously in mice. As the most structurally and morphologically diverse organ in mammals, the placenta also appears to show diverse mechanisms for dosage compensation that may result in differences in conceptus development across species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.