Evidence map›Paper›PMID 22645168›Full record

ArticleBioinformatics (Oxford, England)2012

AS-EAST: a functional annotation tool for putative proteins encoded by alternatively spliced transcripts.

Masafumi Shionyu, Ken-ichi Takahashi, Mitiko Go

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. DBATE: database of alternative transcripts expression.Database : the journal of biological databases and curation · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Masafumi ShionyuDepartment of Computer Bioscience, Nagahama Institute of Bio-Science and Technology, 1266, Tamura-cho, Nagahama, Shiga 526-0829, Japan. m_shionyu@nagahama-i-bio.ac.jp
Ken-ichi Takahashi
Mitiko Go

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryAlternative Splicing Effects ASsessment Tools (AS-EAST) is an online tool for the functional annotation of putative proteins encoded by transcripts generated by alternative splicing (AS). When provided with a transcript sequence, AS-EAST identifies regions altered by AS events in the putative protein sequence encoded by the transcript. Users can evaluate the predicted function of the putative protein by inspecting whether functional domains are included in the altered regions. Moreover, users can infer the loss of inter-molecular interactions in the protein network according to whether the AS events affect interaction residues observed in the 3D structure of the reference isoform. The information obtained from AS-EAST will help to design experimental analyses for the functional significance of novel splice isoforms. AVAILABILITY: The online tool is freely available at http://as-alps.nagahama-i-bio.ac.jp/ASEAST/. CONTACT: m_shionyu@nagahama-i-bio.ac.jp.

Indexed as

Alternative SplicingSoftwareAmino Acid SequenceComputational BiologyProtein IsoformsProteinsUser-Computer InterfaceProtein IsoformsProteins

Identifiers

PMID22645168
PMCPMC3400965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.