ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 35 citations in OpenAlex.
- Pre-treatment risk predictors of valproic acid-induced dyslipidemia in pediatric patients with epilepsy.Frontiers in pharmacology · 2024Article
- The Study of Carotid Artery Intima-Media Thickness in Children With Epilepsy on Anti-Epileptic Drugs.Global pediatric health · 2023Article
- Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies.Journal of personalized medicine · 2022Article
- Targeting the Ghrelin Receptor as a Novel Therapeutic Option for Epilepsy.Biomedicines · 2021Review
- Valproate-Induced Epigenetic Upregulation of Hypothalamic Fto Expression Potentially Linked with Weight Gain.Cellular and molecular neurobiology · 2021Article
- Effects of Antiepileptic Drugs on the Carotid Artery Intima-Media Thickness in Epileptic Patients.Journal of clinical neurology (Seoul, Korea) · 2017Article
- Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity.Current gastroenterology reports · 2016Review
- Atherogenic consequence of antiepileptic drugs: a study of intima-media thickness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Neuroactive peptides as putative mediators of antiepileptic ketogenic diets.Frontiers in neurology · 2014Review
- Importance of accurate measurement of carotid intima-media thickness for evaluating epileptic children treated with valproate.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Article
- Metabolic syndrome and migraine.Frontiers in neurology · 2012Article
- The Serum Prolidase Enzyme Activity as a Biomarker for Evaluation of the Subclinical Vascular Damage in Children with Epilepsy.Annals of Indian Academy of NeurologyArticle
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight gain is a common side effect of valproate (VPA) treatment, although the mechanism is not clear. Abnormal weight gain and obesity are associated with dyslipidemia, hypertension, and atherosclerosis. Measurement of the common carotid artery intima media thickness (CAIMT) gives a picture of early arterial wall alterations and, currently, is considered a noninvasive marker of premature atherosclerosis. The aim of the present study was to evaluate plasma insulin, leptin, neuropeptide Y (NPY), ghrelin, and adiponectin levels in children with epilepsy treated with VPA and to evaluate these parameters for early atherosclerosis. MATERIAL AND
methodsTwenty prepubertal children with idiopathic epilepsy treated with VPA were enrolled in this study. Body mass index (BMI) and fasting insulin glucose ratio (FIGR) were calculated, and the plasma insulin, leptin, NPY, ghrelin, and adiponectin levels; the lipid profiles; and CAIMT were measured for all subjects before the treatment and after a follow-up period of 6 and 12 months.
resultsWhen pretreatment values were compared with those at the end of 6 and 12 months, the mean BMI values, plasma insulin, leptin, NPY levels, and FIGR were increased, whereas the plasma ghrelin and adiponectin levels, lipid profiles, and CAIMT did not change significantly at the end of 6 and 12 months.
conclusionThese results suggest that weight gain during VPA treatment may be related to increases in insulin, leptin, and NPY levels. Additionally, in this study, no increase in the risk for early atherosclerosis was determined by CAIMT in children with epilepsy treated with VPA.
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