ArticleCurrent microbiology2012
Effects of xylitol on xylitol-sensitive versus xylitol-resistant Streptococcus mutans strains in a three-species in vitro biofilm.
Article in Current microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Xylitol Modification of Electrospun Polymer Scaffolds: Impact on Physicochemical and Antibacterial Properties.Polymers · 2025Article
- Isofloridoside: a novel inhibitor of Streptococcus mutans biofilm formation and glucosyltransferase activity.BMC research notes · 2025Article
- Real-time acid production and extracellular matrix formation in mature biofilms of threeBiofilm · 2024Article
- Alteration of oral microbial biofilms by sweeteners.Biofilm · 2024Review
- The Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Oral Cancer Management.Probiotics and antimicrobial proteins · 2023Review
- Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism.Foods (Basel, Switzerland) · 2020Review
- Xylitol and erythritol inhibit real-time biofilm formation of Streptococcus mutans.BMC microbiology · 2020Article
- EvaluatingFrontiers in microbiology · 2018Article
- Effects of Xylitol and Sucrose Mint Products on Streptococcus mutans Colonization in a Dental Simulator Model.Current microbiology · 2017Article
- The use of in vitro model systems to study dental biofilms associated with caries: a short review.Journal of oral microbiology · 2015Article
- Metabolic activity of Streptococcus mutans biofilms and gene expression during exposure to xylitol and sucrose.International journal of oral science · 2014Article
- The effect of xylitol on dental caries and oral flora.Clinical, cosmetic and investigational dentistry · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the effects of xylitol on biofilms containing xylitol-resistant (Xr) and xylitol-sensitive (Xs) Streptococcus mutans, Actinomyces naeslundii and S. sanguinis. The biofilms were grown for 8 and 24 h on hydroxyapatite discs. The viable microorganisms were determined by plate culturing techniques and fluorescence in situ hybridization (FISH) was performed using a S. mutans-specific probe. Extracellular cell-bound polysaccharides (EPS) were determined by spectrofluorometry from single-species S. mutans biofilms. In the presence of 5 % xylitol, the counts of the Xs S. mutans decreased tenfold in the young (8 h) biofilm (p < 0.05) but no effect was seen in the mature (24 h) biofilm. No decrease was observed for the Xr strains, and FISH confirmed these results. No differences were detected in the EPS production of the Xs S. mutans grown with or without xylitol, nor between Xr and Xs S. mutans strains. Thus, it seems that xylitol did not affect the EPS synthesis of the S. mutans strains. Since the Xr S. mutans strains, not inhibited by xylitol, showed no xylitol-induced decrease in the biofilms, we conclude that growth inhibition could be responsible for the decrease of the counts of the Xs S. mutans strains in the clinically relevant young biofilms.
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