ArticleMedical oncology (Northwood, London, England)2012
Growth arrest-specific homeobox is associated with poor survival in patients with hepatocellular carcinoma.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- MEOX2: a homeobox transcription factor with multifaceted biological functions and broad disease associations.Frontiers in cell and developmental biology · 2026Review
- Article
- Angiogenesis related gene signatures predict prognosis and guide therapeutic strategies in renal clear cell carcinoma.Scientific reports · 2025Article
- MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma.Cell death & disease · 2022Article
- Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1.Human molecular genetics · 2022Article
- A Crucial Angiogenesis-Associated Gene MEOX2 Could Be a Promising Biomarker Candidate for Breast Cancer.Frontiers in oncology · 2022Article
- Prognostic significance of MEOX2 in gliomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Article
- Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.American journal of translational research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth arrest-specific homeobox (GAX) codes for a transcription factor and plays a crucial role in many human cancers. Previous tumor studies have shown GAX may act as a suppressor of growth, invasion, and metastasis. However, little is known as to its role in hepatocellular carcinoma (HCC). Our aim was to investigate the expression of GAX in HCC and to make correlations with clinicopathologic features. Twenty-five pairs of HCC and adjacent non-tumor tissues, and six normal liver tissues were collected for GAX detection by Western blotting and real-time-PCR analysis. Immunohistochemistry was used to determine the expression of GAX in HCC and adjacent non-tumor tissues from 96 patients. Reduced expression of GAX was significantly associated with Edmondson stage, vascular invasion, and capsule invasion. Moreover, Kaplan-Meier curves showed that lower GAX expression was associated with shorter overall survival and disease-free survival in HCC patient. In conclusion, our study demonstrates for the first time that downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in HCC patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.