ReviewJournal of cardiovascular translational research2012
What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes.
Review in Journal of cardiovascular translational research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Effect of exercise training on cardiac autonomic function in type 2 diabetes mellitus: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Reactive Hyperemia and Cardiovascular Autonomic Neuropathy in Type 2 Diabetic Patients: A Systematic Review of Randomized and Nonrandomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- The prevalence of cardiac autonomic neuropathy in prediabetes: a systematic review.Diabetologia · 2021Pooled it
- Haemodynamic responses to head-up tilt versus lower-body negative pressure in type 1 diabetes.Experimental physiology · 2026Trial
- Sudomotor dysfunction as a measure of small fiber neuropathy in type 1 diabetes.Autonomic neuroscience : basic & clinical · 2017Trial
- Trial
- Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program.Cardiovascular diabetology · 2014Trial
- Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.Diabetes care · 2014Trial
- Effects of exenatide on measures of diabetic neuropathy in subjects with type 2 diabetes: results from an 18-month proof-of-concept open-label randomized study.Journal of diabetes and its complicationsTrial
- Circulating Neopterin Is Independently Associated with Autonomic Neuropathy in Type 2 Diabetes, but Not with Other Microvascular Complications.Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Cardiac Autonomic Neuropathy and Its Impact on Progression of Diabetic Kidney Disease in Type 1 and Type 2 Diabetes.Kidney medicine · 2025Review
- Autonomic neuropathy in diabetes.Archives of endocrinology and metabolism · 2025Review
- Cardiovascular autonomic neuropathy defined by indices of heart rate variability is associated with cardiovascular disease: a longitudinal cohort study of participants with type 1 diabetes.Cardiovascular diabetology · 2025Article
- The association between resting heart rate and HbA1c-assessed glycemic control in patients with type 2 diabetes in Eastern China.Frontiers in endocrinology · 2025Article
- The Impact of Type 2 Diabetes on Peripheral and Cerebral Hemodynamic Responses to Active Stand.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Cardiovascular autonomic neuropathy and the risk of diabetic kidney disease.Frontiers in endocrinology · 2024Article
- The Retinal Nerve Fiber Layer Thickness Is Associated with Systemic Neurodegeneration in Long-Term Type 1 Diabetes.Translational vision science & technology · 2023Article
- Emerging Therapy for Diabetic Cardiomyopathy: From Molecular Mechanism to Clinical Practice.Biomedicines · 2023Review
- The conundrum of diabetic neuropathies-Past, present, and future.Journal of diabetes and its complications · 2022Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cardiovascular autonomic neuropathy (CAN) in diabetes is generally overlooked in practice, although awareness of its serious consequences is emerging. Challenges in understanding the complex, dynamic changes in the modulation of the sympathetic/parasympathetic systems' tone and their interactions with physiologic mechanisms regulating the control of heart rate, blood pressure, and other cardiovascular functions in the presence of acute hyper-or-hypoglycemic stress, other stressors or medication, and challenges with sensitive evaluations have contributed to lower CAN visibility compared with other diabetes complications. Yet, CAN is a significant cause of morbidity and mortality, due to a high-risk of cardiac arrhythmias, silent myocardial ischemia and sudden death. While striving for aggressive risk factor control in diabetes practice seemed intuitive, recent reports of major clinical trials undermine established thinking concerning glycemic control and cardiovascular risk. This review covers current understanding and gaps in that understanding of the clinical implications of CAN and prevention and treatment of CAN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.