ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Membrane trafficking alterations in breast cancer progression.Frontiers in cell and developmental biology · 2024Review
- Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.BioMed research international · 2024Article
- Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS.Signal transduction and targeted therapy · 2023Review
- Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis.Frontiers in cell and developmental biology · 2021Review
- Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.The Journal of pathology · 2019Article
- Article
- Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.Experimental & molecular medicine · 2018Article
- Rab25 GTPase: Functional roles in cancer.Oncotarget · 2017Review
- Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.Molecular cancer · 2017Article
- High Throughput Analysis of Golgi Structure by Imaging Flow Cytometry.Scientific reports · 2017Article
- RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis.Epigenetics · 2016Article
- Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.Oncotarget · 2016Article
- The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells.Small GTPases · 2015Review
- Rab25 expression predicts poor prognosis in clear cell renal cell carcinoma.Experimental and therapeutic medicine · 2014Article
- 17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells.Oncotarget · 2014Article
- Diversin is overexpressed in breast cancer and accelerates cell proliferation and invasion.PloS one · 2014Article
- A proteomics analysis to evaluate cytotoxicity in NRK-52E cells caused by unmodified Nano-Fe₃O₄.TheScientificWorldJournal · 2014Article
- High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.Cancer medicine · 2013Article
- Endocytosis and cancer.Cold Spring Harbor perspectives in biology · 2013Review
- A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis.Nature reviews. Cancer · 2013Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the most common cancer in women worldwide. Studies have suggested that Ras-related protein 25 (Rab25), a member of Rab small GTPase family, is involved in the pathogenesis of breast cancer. In this study, we investigated whether the expression of Rab25 correlated with lymphatic metastasis in breast cancer and whether the expression of Rab25 was positively correlated with oestrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer. Breast cancer tissues from 42 invasive ductal breast cancer patients with or without lymphatic metastasis were collected and the levels of Rab25 mRNA and protein measured by quantitative real-time PCR and immunohistochemistry, respectively. The mRNA level of Rab25 was significantly increased in invasive ductal breast cancer with lymphatic metastasis compared to that in invasive ductal breast cancer without lymphatic metastasis. Immunohistochemical analysis demonstrated that Rab25 and vascular endothelial growth factor (VEGF) were highly expressed in invasive ductal breast cancer with lymphatic metastasis regardless of whether the cancer is ER and PR positive or negative. Higher expression of Rab25 positively correlated with VEGF expression. However, the expressions of Rab25 in ER and PR-positive cancers were much higher than ER and PR-negative cancers regardless of whether lymphatic metastasis occurred. These data suggest that higher level of Rab25 was associated with lymphatic metastasis, specifically in ER and PR-positive breast cancer. The better understanding of the mechanism of Rab25 may provide a basis for the development of a novel therapeutic target in breast cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.