ArticleFolia microbiologica2012
Structural characterization and surface activities of biogenic rhamnolipid surfactants from Pseudomonas aeruginosa isolate MN1 and synergistic effects against methicillin-resistant Staphylococcus aureus.
Article in Folia microbiologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- An optimized, rhamnolipid-containing cell-free filtrate fromFrontiers in plant science · 2026Article
- Phage-antibiotic synergy to combat multidrug resistant strains of Gram-negative ESKAPE pathogens.Scientific reports · 2025Article
- Microbe cultivation guidelines to optimize rhamnolipid applications.Scientific reports · 2024Article
- Biosurfactant complexed with arginine has antibiofilm activity against methicillin-resistantFuture microbiology · 2024Article
- Chemical and biological evaluation of biosurfactant fractions from Wickerhamomyces anomalus CCMA 0358.Applied microbiology and biotechnology · 2023Article
- Differential Spreading of Rhamnolipid Congeners fromACS applied bio materials · 2023Article
- Evaluation of Antimicrobial Properties and Potential Applications ofPharmaceutics · 2023Article
- Biological Control ofMicroorganisms · 2022Review
- Cobalt Bis-Dicarbollide Enhances Antibiotics Action towardsPharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Rhamnolipids as Effective Green Agents in the Destabilisation of Dolomite Suspension.International journal of molecular sciences · 2021Article
- Toxicity Profiling of Biosurfactants Produced by Novel Marine Bacterial Strains.International journal of molecular sciences · 2021Article
- ROS-Mediated Necrosis by Glycolipid Biosurfactants on Lung, Breast, and Skin Melanoma Cells.Frontiers in oncology · 2021Article
- Surface sensing triggers a broad-spectrum antimicrobial response in Pseudomonas aeruginosa.Environmental microbiology · 2020Article
- Evaluation of Anti-oxidant and Anti-biofilm Activities of Biogenic Surfactants Derived fromIranian journal of pharmaceutical research : IJPR · 2020Article
- High Di-rhamnolipid Production UsingFrontiers in bioengineering and biotechnology · 2019Article
- Variants of lipopeptides and glycolipids produced by Bacillus amyloliquefaciens and Pseudomonas aeruginosa cultured in different carbon substrates.AMB Express · 2017Article
- Effect of biosurfactants on Pseudomonas aeruginosa and Staphylococcus aureus biofilms in a BioFlux channel.Applied microbiology and biotechnology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of present work was to study chemical structures and biological activities of rhamnolipid biosurfactants produced by Pseudomonas aeruginosa MN1 isolated from oil-contaminated soil. The results of liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis revealed that total rhamnolipids (RLs) contained 16 rhamnolipid homologues. Di-lipid RLs containing C(10)-C(10) moieties were by far the most predominant congeners among mono-rhamnose (53.29 %) and di-rhamnose (23.52 %) homologues. Mono-rhamnolipids form 68.35 % of the total congeners in the RLs. Two major fractions were revealed in the thin layer chromatogram of produced RLs which were then purified by column chromatography. The retardation factors (R (f)) of the two rhamnolipid purple spots were 0.71 for RL1 and 0.46 for RL2. LC-MS/MS analysis proved that RL1 was composed of mono-RLs and RL2 consisted of di-RLs. RL1 was more surface-active with the critical micelle concentration (CMC) value of 15 mg/L and the surface tension of 25 mN/m at CMC. The results of biological assay showed that RL1 is a more potent antibacterial agent than RL2. All methicillin-resistant Staphylococcus aureus (MRSA) strains were inhibited by RLs that were independent of their antibiotic susceptibility patterns. RLs remarkably enhanced the activity of oxacillin against MRSA strains and lowered the minimum inhibitory concentrations of oxacillin to the range of 3.12-6.25 μg/mL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.