ArticleAmerican journal of primatology2012
From the mouths of monkeys: detection of Mycobacterium tuberculosis complex DNA from buccal swabs of synanthropic macaques.
Article in American journal of primatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Diagnostic accuracy of oral swab for detection of pulmonary tuberculosis: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Non-invasive environmental DNA sampling reveals tuberculosis risks at the human - Great Ape Interface in Africa.Emerging microbes & infections · 2026Article
- Advancing tuberculosis diagnosis and management in cynomolgus macaques using Xpert MTB/RIF ultra assay.Scientific reports · 2024Article
- Pathologic characteristics of infectious diseases in macaque monkeys used in biomedical and toxicologic studies.Journal of toxicologic pathology · 2023Review
- Non-invasive specimen collections for Mycobacterium tuberculosis detection in free-ranging long-tailed macaques (Macaca fascicularis).PloS one · 2023Article
- Viruses in saliva from sanctuary chimpanzees (Pan troglodytes) in Republic of Congo and Uganda.PloS one · 2023Article
- Gene-Based Diagnosis of Tuberculosis from Oral Swabs with a New Generation Pathogen Enrichment Technique.Microbiology spectrum · 2022Article
- Zoonotic pathogens survey in free-living long-tailed macaques in Thailand.International journal of veterinary science and medicine · 2022Article
- Detection of Mycobacterium tuberculosis complex antibodies in free-ranged wild boar and wild macaques in selected districts in Selangor and reevaluation of tuberculosis serodetection in captive Asian elephants in Pahang, Peninsular Malaysia.The Journal of veterinary medical science · 2021Article
- Optimizing a Noninvasive Oral Sampling Technique for Semicaptive Neotropical Primates in Peru.Journal of wildlife diseases · 2020Article
- Article
- Microbiological diagnosis of pulmonary tuberculosis in children by oral swab polymerase chain reaction.Scientific reports · 2019Article
- Noninvasive Detection of Tuberculosis by Oral Swab Analysis.Journal of clinical microbiology · 2019Article
- Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife.Frontiers in veterinary science · 2019Article
- Mycobacterium leprae genomes from naturally infected nonhuman primates.PLoS neglected tropical diseases · 2018Article
- Survey of Treponemal Infections in Free-Ranging and Captive Macaques, 1999-2012.Emerging infectious diseases · 2017Article
- Mycobacterium tuberculosis infections in cynomolgus monkey transplant recipients and institution of a screening program for the prevention and control of tuberculosis.BMC veterinary research · 2016Article
- Noninvasive Tuberculosis Screening in Free-Living Primate Populations in Gombe National Park, Tanzania.EcoHealth · 2016Article
- Validation of qPCR Methods for the Detection of Mycobacterium in New World Animal Reservoirs.PLoS neglected tropical diseases · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 7 countries.
Funding
Abstract
Although the Mycobacterium tuberculosis complex (MTBC) infects a third of all humans, little is known regarding the prevalence of mycobacterial infection in nonhuman primates (NHP). For more than a century, tuberculosis has been regarded as a serious infectious threat to NHP species. Advances in the detection of MTBC open new possibilities for investigating the effects of this poorly understood pathogen in diverse populations of NHP. Here, we report results of a cross-sectional study using well-described molecular methods to detect a nucleic acid sequence (IS6110) unique to the MTBC. Sample collection was focused on the oral cavity, the presumed route of transmission of MTBC. Buccal swabs were collected from 263 macaques representing 11 species in four Asian countries and Gibraltar. Contexts of contact with humans included free ranging, pets, performing monkeys, zoos, and monkey temples. Following DNA isolation from buccal swabs, the polymerase chain reaction (PCR) amplified IS6110 from 84 (31.9%) of the macaques. In general, prevalence of MTBC DNA was higher among NHP in countries where the World Health Organization reports higher prevalence of humans infected with MTBC. This is the first demonstration of MTBC DNA in the mouths of macaques. Further research is needed to establish the significance of this finding at both the individual and population levels. PCR of buccal samples holds promise as a method to elucidate the mycobacterial landscape among NHP, particularly macaques that thrive in areas of high human MTBC prevalence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.