ArticleJournal of industrial microbiology & biotechnology2012
Horizontal gene transfer and gene conversion drive evolution of modular polyketide synthases.
Article in Journal of industrial microbiology & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Evolutionary strategies of late-stage diversification in bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
- Graph neural networks can predict ketosynthase substrate specificity.Scientific reports · 2026Article
- Gene conversion-associated successive engineering of modular polyketide synthases.Communications chemistry · 2025Article
- Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria.Angewandte Chemie (International ed. in English) · 2025Article
- Synteruptor: mining genomic islands for non-classical specialized metabolite gene clusters.NAR genomics and bioinformatics · 2024Article
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Evolution and Diversity of Assembly-Line Polyketide Synthases.Chemical reviews · 2019Review
- Methylamine-specific methyltransferase paralogs in Methanosarcina are functionally distinct despite frequent gene conversion.The ISME journal · 2019Article
- Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.Journal of industrial microbiology & biotechnology · 2016Article
- Biased Gene Conversion in Rhizobium etli Is Caused by Preferential Double-Strand Breaks on One of the Recombining Homologs.Journal of bacteriology · 2016Article
- Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination.Journal of the American Chemical Society · 2015Article
- A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis.PLoS computational biology · 2014Article
- Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase.Journal of molecular biology · 2014Article
- Evolutionary concepts in natural products discovery: what actinomycetes have taught us.Journal of industrial microbiology & biotechnology · 2014Review
- Databases of the thiotemplate modular systems (CSDB) and their in silico recombinants (r-CSDB).Journal of industrial microbiology & biotechnology · 2013Article
- Annotation of the modular polyketide synthase and nonribosomal peptide synthetase gene clusters in the genome of Streptomyces tsukubaensis NRRL18488.Applied and environmental microbiology · 2012Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Soil bacteria live in a very competitive environment and produce many secondary metabolites; there appears to be strong selective pressure for evolution of new compounds. Secondary metabolites are the most important source of chemical structures for the pharmaceutical industry and an understanding of the evolutionary process should help in finding novel chemical entities. Modular polyketide synthases are a particularly interesting case for evolutionary studies, because much of the chemical structure can be predicted from DNA sequence. Previous evolutionary studies have concentrated on individual modules or domains and were not able to study the evolution of orthologues. This study overcame this problem by considering complete clusters as "organisms", so that orthologous modules and domains could be identified and used to characterise evolutionary pathways. Seventeen modular polyketide synthase clusters were identified that fell into six classes. Gene conversion within clusters was very common (affecting about 15 % of domains) and was detected by discordance in phylogenetic trees. An evolutionary model is proposed in which a single cross over between two different clusters (i.e. horizontal gene transfer) would generate a cluster of very different architecture with radically different chemical products; subsequent gene conversion and deletions would explore chemical variants. Two probable examples of such recombination were found. This model suggests strategies for detecting horizontal gene transfer in cluster evolution.
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