SynthesisFamilial cancer2012
The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.
Synthesis in Familial cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Analysis of IL10 gene promoter haplotypes and changes in mRNA expression and soluble levels in patients with basal cell carcinoma.Archives of dermatological research · 2025Article
- Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.Anticancer research · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-10 (IL-10) plays a key role in immunosuppressive and anti-angiogenic process, suggesting its possible involvement in carcinogenesis. A haplotype formed by polymorphisms at positions -1082 G/A (rs1800896), -819 T/C (rs1800871), and -592 A/C (rs1800872) from the transcriptional start site in the promoter region of the IL-10 gene is a strong determinant for IL-10 production. We systematically reviewed the evidence of association between IL-10 promoter haplotype and cancer risk. Up to November 2011, databases including PubMed, and CNKI (China National Knowledge Infrastructure) were searched to access the relevant genetic association studies. Summary odds ratios and corresponding 95% confidence intervals (CIs) for this haplotype and cancer risk were estimated by using fixed or random-effect models when appropriate. Finally, 12 case-control studies with 2,090 cases and 4,224 controls were available for this study. The summary OR for cancer risk associated with the GCC haplotype was 1.47 (95 % CIs = 1.25-1.72) when compared with ATA haplotype by random effects model. Similarly, significantly increased risks were observed both in Caucasian and in Non Caucasian. Our results suggested that haplotype in IL-10 promoter was involved in the development of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.