ArticlePsychopharmacology2012
Reduced activity at the 5-HT(2C) receptor enhances reversal learning by decreasing the influence of previously non-rewarded associations.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
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- Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.Physiology & behavior · 2017Article
- The neural basis of reversal learning: An updated perspective.Neuroscience · 2017Review
- The serotonergic system and cognitive function.Translational neuroscience · 2016Review
- The role of 5-HT2C receptors in touchscreen visual reversal learning in the rat: a cross-site study.Psychopharmacology · 2015Article
- The rat's not for turning: Dissociating the psychological components of cognitive inflexibility.Neuroscience and biobehavioral reviews · 2015Review
- Animal models of obsessive-compulsive disorder: utility and limitations.Neuropsychiatric disease and treatment · 2015Review
- Dissecting impulsivity and its relationships to drug addictions.Annals of the New York Academy of Sciences · 2014Review
- Impact of serotonin (5-HT)2C receptors on executive control processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Impulsive action in the 5-choice serial reaction time test in 5-HT₂c receptor null mutant mice.Psychopharmacology · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleReversal learning deficits are a feature of many human psychopathologies and their associated animal models and have recently been shown to involve the 5-HT(2C) receptor (5-HT(2C)R). Successful reversal learning can be reduced to two dissociable cognitive mechanisms, to dissipate associations of previous positive (opposed by perseverance) and negative (opposed by learned non-reward) valence.
objectivesThis study aims to explore the effect of reducing activity at the 5-HT(2C)R on the cognitive mechanisms underlying spatial reversal learning in the mouse.
methodsExperiment 1 used the 5-HT(2C)R antagonist SB242084 (0.5 mg/kg) in a between-groups serial design, experiment 2 used 5-HT(2C)R KO mice in a repeated measures design. Animals initially learned to discriminate between two lit nosepoke holes. This was followed by three conditions; (1) full reversal, where contingencies reversed; (2) perseverance, where the previous CS+ became CS- and the previous CS- was replaced by a novel CS+; (3) learned non-reward, where the previous CS- became CS+ and the previous CS+ was replaced by a novel CS-.
resultsSB242084 treated and 5-HT(2C)R KO mice showed enhanced reversal learning seen as a decrease in trials, correct responses, and omissions to criterion in the full reversal condition. Similar effects were observed in the learned non-reward condition but SB242084 treated and 5-HT(2C)R KO mice did not differ from controls in the perseverance condition. SB242084 treated, but not 5-HT(2C)R KO mice, showed decreases in all latency indices in every condition.
conclusionReducing activity at the 5-HT(2C)R facilitates reversal learning in the mouse by reducing the influence of previously non-rewarded associations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.