SynthesisAIDS and behavior2012
The impact of DSM-IV mental disorders on adherence to combination antiretroviral therapy among adult persons living with HIV/AIDS: a systematic review.
Synthesis in AIDS and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489667 (HIV + Service Delivery and Telemedicine Through Effective PROs), which is not on this map. Cited by 111 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
HIV + Service Delivery and Telemedicine Through Effective PROs (+STEP)
Who cites it
111 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- The Global Landscape of the Burden of Depressive Symptoms/Major Depression in Individuals Living With HIV/AIDs and Its Effect on Antiretroviral Medication Adherence: An Umbrella Review.Frontiers in psychiatry · 2022Pooled it
- Psychiatric Disorders in Adolescents Living with HIV and Association with Antiretroviral Therapy Adherence in Sub-Saharan Africa: A Systematic Review and Meta-analysis.AIDS and behavior · 2021Pooled it
- Psychosocial interventions enhance HIV medication adherence: A systematic review and meta-analysis.Journal of health psychology · 2020Pooled it
- Posttraumatic Stress Disorder and Nonadherence to Treatment in People Living With HIV: A Systematic Review and Meta-analysis.Frontiers in psychiatry · 2020Pooled it
- Posttraumatic stress disorder and nonadherence to medications prescribed for chronic medical conditions: A meta-analysis.Journal of psychiatric research · 2018Pooled it
- Predictors of Adult Retention in HIV Care: A Systematic Review.AIDS and behavior · 2018Pooled it
- Antidepressants for depression in adults with HIV infection.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Mindfulness-Based Stress Reduction for Symptom Management in Older Individuals with HIV-Associated Neurocognitive Disorder.AIDS and behavior · 2024Trial
- Is Abstinence from Alcohol and Smoking Associated with Less Anxiety and Depressive Symptoms Among People with HIV?AIDS and behavior · 2024Trial
- Mental Health Conditions and Nonpersistence of Direct Oral Anticoagulant Use in Patients With Incident Atrial Fibrillation: A Nationwide Cohort Study.Journal of the American Heart Association · 2022Trial
- Telephone-Delivered Mindfulness Training to Promote Medication Adherence and Reduce Sexual Risk Behavior Among Persons Living with HIV: An Exploratory Clinical Trial.AIDS and behavior · 2020Trial
- Investigating the impact of a community home-based care on mental health and anti-retroviral therapy adherence in people living with HIV in Nepal: a community intervention study.BMC infectious diseases · 2018Trial
- Phone-delivered mindfulness training to promote medication adherence and reduce sexual risk behavior among persons living with HIV: Design and methods.Contemporary clinical trials · 2017Trial
- Individualized texting for adherence building (iTAB): improving antiretroviral dose timing among HIV-infected persons with co-occurring bipolar disorder.AIDS and behavior · 2015Trial
- A preliminary RCT of CBT-AD for adherence and depression among HIV-positive Latinos on the U.S.-Mexico border: the Nuevo Día study.AIDS and behavior · 2013Trial
- Healthcare Utilization and Costs in People Living with HIV and Neuropsychiatric Disorders in the United States.Advances in therapy · 2026Article
- Pregnancy and postpartum cannabis and alcohol use among people with HIV in the United States.Pregnancy (Hoboken, N.J.) · 2026Article
- Antiretroviral therapy persistence among treatment-experienced people with HIV and mental health disorders and/or substance use disorders in the USA (2017-2024): a retrospective cohort study.Journal of comparative effectiveness research · 2026Article
- Real-World Persistence in Adults with HIV and Mental Health or Substance Use Disorders After Restarting Antiretroviral Therapy in the United States.Advances in therapy · 2025Observational
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This is a systematic review of eighty-two published studies investigating the impact of DSM-IV mental disorders on combination antiretroviral therapy (cART) adherence and persistence among persons living with HIV/AIDS (PLWHA). Sixty-two articles examined depression, with 58 % (N = 32/62) finding lower cART adherence and persistence. Seventeen articles examined one or more anxiety disorders, with the majority finding no association with cART adherence or persistence. Eighty percent of the studies that evaluated the impact of psychotic (N = 3), bipolar (N = 5) and personality disorders (N = 2) on cART adherence and persistence also found no association. Seven out of the nine studies (78 %) evaluating the impact of antidepressant treatment (ADT) on cART adherence found improvement. Adherence and depression measurements varied significantly in studies; common research measurements would improve data harmonization. More research specifically addressing the impact of other mental disorders besides depression on cART adherence and RCTs evaluating ADT on cART adherence are also needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.