Cdt1 throws kinetochore-microtubule attachments for a loop.

Daniel R Matson, P Todd Stukenberg

Abstract readNewsComment

In one paragraph

Article in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.Bioorganic chemistry · 2021
Article
Effect of NDC80 in human hepatocellular carcinoma.World journal of gastroenterology · 2017
Article
Coiled-coils: The long and short of it.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016
Review
Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.PLoS genetics · 2016
Article
Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Chromosoma · 2015
Review
The KMN protein network--chief conductors of the kinetochore orchestra.Journal of cell science · 2012
Review

4 · The record

Corrections and comments

Comment on
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.2012

5 · Who and what money

Authors and funding

2 authors.

Daniel R Matson

P Todd Stukenberg

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024

$13.4M

TRAINING IN CELL AND MOLECULAR BIOLOGYT32GM008136 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STUKENBERG, P. TODD · 1985 to 2020

$8.5M

Dissection of the Inner Centromere Regulatory NetworkR01GM063045 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BEKIRANOV, STEFAN, STUKENBERG, P. TODD · 2001 to 2013

$4.0M

NIGMS NIH HHS R01 GM063045NIGMS NIH HHS T32 GM008136

6 · The paper itself

Abstract

The Ndc80 complex links spindle microtubules to the kinetochore to ensure the proper segregation of chromosomes during mitosis. Analysis of the replication licensing factor Cdt1 during mitosis now reveals a cooperative role with the Ndc80 complex in establishing stable microtubule attachments to the spindle.

Indexed as

Cell Cycle ProteinsCytoskeletal ProteinsHumansKinetochoresMicrotubulesNuclear ProteinsCDT1 protein, humanCell Cycle ProteinsCytoskeletal ProteinsNDC80 protein, humanNuclear Proteins

Identifiers

PMID22643874

DOI10.1038/ncb2513

PMCPMC3600811

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.