ReviewJournal of molecular medicine (Berlin, Germany)2012
Human induced pluripotent stem cells--from mechanisms to clinical applications.
Review in Journal of molecular medicine (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Krüppel-like factors in mitochondrial quality control.Frontiers in physiology · 2025Review
- The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review.Cellular and molecular neurobiology · 2023Review
- Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models.Cells · 2022Review
- Human iPSC-Derived Vascular Smooth Muscle Cells in a Fibronectin Functionalized Collagen Hydrogel Augment Endothelial Cell Morphogenesis.Bioengineering (Basel, Switzerland) · 2021Article
- Video bioinformatics analysis of human pluripotent stem cell morphology, quality, and cellular dynamics.Stem cells translational medicine · 2021Article
- Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity.Frontiers in cell and developmental biology · 2021Review
- Article
- Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks.Scientific reports · 2017Article
- Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing.Journal of visualized experiments : JoVE · 2017Article
- Decreased cytoplasmic expression of Raptor correlates with disease progression and unfavorable prognosis in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2017Article
- Characterization and Prospective of Human Corneal Endothelial Progenitors.International journal of medical sciences · 2017Review
- Generation of Induced Pluripotent Stem Cells from Frozen Buffy Coats using Non-integrating Episomal Plasmids.Journal of visualized experiments : JoVE · 2015Article
- Genome modification leads to phenotype reversal in human myotonic dystrophy type 1 induced pluripotent stem cell-derived neural stem cells.Stem cells (Dayton, Ohio) · 2015Article
- Perspectives of induced pluripotent stem cells for cardiovascular system regeneration.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Metabolic restructuring and cell fate conversion.Cellular and molecular life sciences : CMLS · 2015Review
- Improved efficiency of definitive endoderm induction from human induced pluripotent stem cells in feeder and serum-free culture system.In vitro cellular & developmental biology. Animal · 2015Article
- Interaction between nonviral reprogrammed fibroblast stem cells and trophic factors for brain repair.Molecular neurobiology · 2014Article
- Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells.The Journal of cell biology · 2014Article
- Efficient and scalable expansion of human pluripotent stem cells under clinically compliant settings: a view in 2013.Annals of biomedical engineering · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human pluripotent stem cells hold great promise for basic research and regenerative medicine due to their inherent property to propagate infinitely, while maintaining the potential to differentiate into any given cell type of the human body. Since the first derivation in 1998, pluripotent human embryonic stem cells (ESCs) have been studied intensively, and although these cells provoke ethical and immune rejection concerns, translation of human ESC research into the clinics has been initiated. The generation of embryonic stem cell-like human induced pluripotent stem cells (iPSCs) from somatic cells by virus-mediated overexpression of distinct sets of reprogramming factors (OCT4, SOX2, KLF4, and c-MYC, or OCT4, SOX2, NANOG, and LIN28) in 2007 has opened up further opportunities in the field. While circumventing the major disputes associated with human ESCs, iPSCs offer the same advantages and, in addition, new perspectives for personalized medicine. This review summarizes technical advances toward the generation of potentially clinically relevant human iPSCs. We also highlight key molecular events underlying the process of cellular reprogramming and discuss inherent features of iPSCs, including genome instability and epigenetic memory. Furthermore, we will give an overview of particular envisaged human iPSC applications and point out which improvements are yet to come and what has been achieved so far.
Indexed as
Identifiers
22643868What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.