ArticleAmino acids2013
Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated.
Article in Amino acids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men.The journal of nutrition, health & aging · 2019Trial
- Impact of Prematurity on Nutrient Signaling and Protein Synthesis in Skeletal Muscle.Annual review of nutrition · 2026Review
- Amino Acid Signaling in Skeletal Muscle Is Blunted by Prematurity in a Piglet Model.The Journal of nutrition · 2026Article
- Feeding style alters the growth and behavior of artificially-reared pigs.Journal of animal science · 2025Article
- Development of an ultra-sensitive laser stimulated fluorescence system for simultaneous detection of amino acids.RSC advances · 2024Article
- Review: Nutritional regulation of muscle growth in neonatal swine.Animal : an international journal of animal bioscience · 2023Review
- Maternal pyrimidine nucleoside supplementation regulates fatty acid, amino acid and glucose metabolism of neonatal piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Enhanced small neutral but not branched chain amino acid transport after epigenetic sodium coupled neutral amino acid transporter-2 (SNAT2) cDNA expression in myoblasts.Journal of cachexia, sarcopenia and muscle · 2021Article
- Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.American journal of physiology. Endocrinology and metabolism · 2021Article
- Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.Annual review of animal biosciences · 2019Review
- Regulation and function of the SLC38A3/SNAT3 glutamine transporter.Channels (Austin, Tex.) · 2016Review
- Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia.Pediatric research · 2016Article
- Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[Toxicology research · 2016Article
- Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs.American journal of physiology. Endocrinology and metabolism · 2016Article
- Dietary leucine supplementation minimises tumour-induced damage in placental tissues of pregnant, tumour-bearing rats.BMC cancer · 2016Article
- Amino acid composition in eyes from zebrafish (Danio rerio) and sardine (Sardina pilchardus) at the larval stage.SpringerPlus · 2016Article
- Effects of dietary leucine supplementation on the gene expression of mammalian target of rapamycin signaling pathway and intestinal development of broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2015Article
- Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.Amino acids · 2014Article
- Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells.Physiological reports · 2014Article
- Amino acid transporters in the regulation of human skeletal muscle protein metabolism.Current opinion in clinical nutrition and metabolic care · 2013Review
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Authors and funding
4 authors.
Funding
Abstract
Previously we demonstrated that the insulin- and amino acid-induced activation of the mammalian target of rapamycin complex 1 (mTORC1) is developmentally regulated in neonatal pigs. Recent studies have indicated that members of the System A transporter (SNAT2), the System N transporter (SNAT3), the System L transporters (LAT1 and LAT2), and the proton-assisted amino acid transporters (PAT1 and PAT2) have crucial roles in the activation of mTORC1 and that the abundance of amino acid transporters is positively correlated with their activation. This study aimed to determine the effect of the post-prandial rise in insulin and amino acids on the abundance or activation of SNAT2, SNAT3, LAT1, LAT2, PAT1, and PAT2 and whether the response is modified by development. Overnight fasted 6- and 26-day-old pigs were infused for 2 h with saline (Control) or with insulin or amino acids to achieve fed levels while amino acids or insulin, respectively, as well as glucose were maintained at fasting levels. The abundance of SNAT2, SNAT3, LAT1, LAT2, PAT1, and PAT2 was higher in muscle of 6- compared with 26-day-old pigs. The abundance of the PAT2-mTOR complex was greater in 6- than in 26-day-old pigs, consistent with the higher activation of mTORC1. Neither insulin nor amino acids altered amino acid transporter or PAT2-mTOR complex abundance. In conclusion, the amino acid transporters, SNAT 2/3, LAT 1/2, and PAT1/2, likely have important roles in the enhanced amino acid-induced activation of mTORC1 in skeletal muscle of the neonate.
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