ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Mammalian Neuraminidases in Immune-Mediated Diseases: Mucins and Beyond.Frontiers in immunology · 2022Pooled it
- How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection.Immunological reviews · 2026Review
- Role of the cAMP-PKA-NF-κB pathway in Mucin1 over-expression in A549 cells during Respiratory syncytial virus infection.BMC infectious diseases · 2023Article
- Innate immune responses in pneumonia.Pneumonia (Nathan Qld.) · 2023Review
- Mucus and Mucins: The Underappreciated Host Defence System.Frontiers in cellular and infection microbiology · 2022Review
- Epithelial Barrier Dysfunction in Chronic Respiratory Diseases.Frontiers in physiology · 2021Review
- Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2.mBio · 2020Review
- MUC1 contributes to goblet cell metaplasia and MUC5AC expression in response to cigarette smoke in vivo.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Integrative Physiology of Pneumonia.Physiological reviews · 2018Review
- Mucus models to evaluate the diffusion of drugs and particles.Advanced drug delivery reviews · 2018Review
- MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells.Frontiers in immunology · 2018Review
- MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function.Journal of clinical medicine · 2017Review
- The cell surface mucin MUC1 limits the severity of influenza A virus infection.Mucosal immunology · 2017Article
- Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway.Biochemical and biophysical research communications · 2017Article
- MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.Journal of innate immunity · 2017Review
- Regulation of Airway Inflammation by G-protein Regulatory Motif Peptides of AGS3 protein.Scientific reports · 2016Article
- Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages.American journal of respiratory cell and molecular biology · 2016Article
- Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- The Interaction between Respiratory Pathogens and Mucus.Cell host & microbe · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
OBJECTIVE AND
designTo determine whether repetitive airway Pseudomonas aeruginosa (Pa) infection results in lung inflammation and injury and, if so, whether these responses are affected by Muc1 mucin. Muc1 wild type (WT) and knockout (KO) mice were compared for body weights, lung inflammatory responses, and airspace enlargement using a chronic lung infection model system. MATERIALS: Mice were treated intranasally with Pa (10(7) CFU) on days 0, 4, 7 and 10. On day 14, body weights, inflammatory cell numbers in bronchoalveolar lavage fluid (BALF), and airspace enlargement were measured. Differences in inflammatory responses between groups were statistically analyzed by the Student's t test and ANOVA.
resultsMuc1 WT mice exhibited mild degrees of both inflammation and airspace enlargement following repetitive airway Pa infection. However, Muc1 KO mice exhibited significantly decreased body weights, greater macrophage numbers in the BALF, and increased airspace enlargement compared with Muc1 WT mice.
conclusionsThis is the first report demonstrating that Muc1 deficiency can lead to lung injury during chronic Pa infection in mice. These results suggest that MUC1 may play a crucial role in the resolution of inflammation during chronic respiratory infections and that MUC1 dysfunction likely contributes to the pathogenesis of chronic inflammatory respiratory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.