ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Use of blood urea nitrogen, creatinine, interleukin-6, granulocyte-macrophage colony stimulating factor in combination to predict the severity and outcome of abdominal sepsis in rats.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of Shenfu injection on intestinal microbiota and inflammation in sepsis mice.Frontiers in cellular and infection microbiology · 2025Article
- Effect of Celecoxib and Infliximab against Multiple Organ Damage Induced by Sepsis in Rats: A Comparative Study.Biomedicines · 2022Article
- [Comparison of four scoring systems for predicting ICU mortality in patients with sepsis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis.Mediators of inflammation · 2020Article
- Inflammatory Cytokine and Chemokine Patterns in Paediatric Patients with Suspected Serious Bacterial Infection.Medicina (Kaunas, Lithuania) · 2019Article
- Intravenous delivery of granulocyte-macrophage colony stimulating factor impairs survival in lipopolysaccharide-induced sepsis.PloS one · 2019Article
- Article
- The significance of routine biochemical markers in patients with major depressive disorder.Scientific reports · 2016Article
- Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice.Scientific reports · 2015Article
- Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.Clinical and experimental immunology · 2015Article
- Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy.International journal of molecular sciences · 2015Article
- Elevated blood urea nitrogen and medical outcome of psychiatric inpatients.The Psychiatric quarterly · 2014Article
- Protein kinase G oxidation is a major cause of injury during sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAccurate and timely diagnosis and prognosis of sepsis remain challenging. A combination of markers, as opposed to single ones, may improve the prognosis, and therefore survival. This study compared the effectiveness of routinely used biomarkers of sepsis alone and in combination for the prediction of outcome in rats with abdominal sepsis.
methodsRats were subjected to sepsis induced by cecal ligation and puncture (CLP). Seventeen biomarkers were detected 12 h after the CLP. Correlation between the biomarkers and outcome of rats was analyzed; the correlated biomarkers were analyzed by logistic regression analysis and the area under the receiver operating characteristic (ROC) curve was computed to compare their performance in the prognosis of sepsis.
resultsA total of 49 rats were eligible for analysis. Body temperature (T), blood urea nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT), creatine kinase (CK), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) levels after the CLP were negatively correlated with the survival outcome, while platelet count (PLT), high-mobility group box protein 1 (HMGB1) and granulocyte-macrophage colony stimulating factor (GM-CCF) were positively correlated with the survival outcome (P < 0.05). Levels of BUN, Cr, IL-6, and GM-CSF after the CLP were independent predictors of outcome according to conditional logistic regression. The sensitivity and specificity of the four selected biomarkers in combination for predicting sepsis outcome were better than single ones (P < 0.05).
conclusionA combination of different biomarkers improves the diagnostic accuracy and is more effective in the prognosis of sepsis in rats. Use of BUN, Cr, IL-6, GM-CSF in combination to predict the severity and outcome in rats with abdominal sepsis exhibited acceptable diagnostic characteristics.
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