Evidence map›Paper›PMID 22643349›Full record

ArticleGastroenterology2012

Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping.

Gregory O'Grady, Timothy R Angeli, Peng Du, Chris Lahr, Wim J E P Lammers, John A Windsor, Thomas L Abell, Gianrico Farrugia, Andrew J Pullan, Leo K Cheng

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 7 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 7 syntheses or guidelines pooled it, 324 citations in OpenAlex.

  1. Pooled it
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  7. Gastric dysrhythmia in gastroesophageal reflux disease: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2021
    Pooled it
  8. Trial
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  12. Methods and Techniques for Closed-Loop Gastrointestinal Pacing.Neurogastroenterology and motility · 2026
    Article
  13. Gastric slow-wave morphology in health and disease.Digestive diseases and sciences · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Gregory O'GradyDepartment of Surgery, University of Auckland, Auckland, New Zealand; Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand. Electronic address: gog@ps.gen.nz.
Timothy R AngeliAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Peng DuAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Chris LahrDivision of Gastroenterology, University of Mississippi Medical Center, Jackson, Mississippi.
Wim J E P LammersAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Physiology, UAE University, United Arab Emirates.
John A WindsorDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Thomas L AbellDivision of Gastroenterology, University of Mississippi Medical Center, Jackson, Mississippi.
Gianrico FarrugiaDivision of Enteric Neurosciences, Mayo Clinic, Rochester, Minnesota.
Andrew J PullanAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Surgery, Vanderbilt University, Nashville, Tennessee.
Leo K ChengAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand; Department of Surgery, Vanderbilt University, Nashville, Tennessee.
University of Auckland · NZJackson Memorial Hospital · USMayo Clinic · USUnited Arab Emirates University · AEUniversity of Mississippi Medical Center · USVanderbilt University · US

Funding

Physiological Characterization and Data Integration CoreP01DK068055 · NIDDK · MAYO CLINIC ROCHESTER · PI ORDOG, TAMAS · 2004 to 2019
$23.8M
Gastroparesis Consortium Continuation-Data Coordinating CenterU01DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2006 to 2015
$17.4M
CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis ConsortiumU01DK074007 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Thomas Lyman Abell · 2006 to 2026
$7.0M
The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of GastU01DK074035 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irene Sarosiek · 2008 to 2026
$6.7M
Realistic models of gastrointestinal bioelectromagnetismR01DK064775 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHENG, LEO · 2004 to 2014
$2.6M
NIDDK NIH HHS P01 DK068055NIDDK NIH HHS R01 DK064775NIDDK NIH HHS R01 DK64775NIDDK NIH HHS U01 DK074007NIDDK NIH HHS U01DK074007NIDDK NIH HHS U01 DK074008NIDDK NIH HHS U01DK074008NIDDK NIH HHS U01 DK074035
6 · The paper itself

Abstract

BACKGROUND &

aimsInterstitial cells of Cajal (ICC) generate slow waves. Disrupted ICC networks and gastric dysrhythmias are each associated with gastroparesis. However, there are no data on the initiation and propagation of slow waves in gastroparesis because research tools have lacked spatial resolution. We applied high-resolution electrical mapping to quantify and classify gastroparesis slow-wave abnormalities in spatiotemporal detail.

methodsSerosal high-resolution mapping was performed using flexible arrays (256 electrodes; 36 cm(2)) at stimulator implantation in 12 patients with diabetic or idiopathic gastroparesis. Data were analyzed by isochronal mapping, velocity and amplitude field mapping, and propagation animation. ICC numbers were determined from gastric biopsy specimens.

resultsMean ICC counts were reduced in patients with gastroparesis (2.3 vs 5.4 bodies/field; P < .001). Slow-wave abnormalities were detected by high-resolution mapping in 11 of 12 patients. Several new patterns were observed and classified as abnormal initiation (10/12; stable ectopic pacemakers or diffuse focal events; median, 3.3 cycles/min; range, 2.1-5.7 cycles/min) or abnormal conduction (7/10; reduced velocities or conduction blocks; median, 2.9 cycles/min; range, 2.1-3.6 cycles/min). Circumferential conduction emerged during aberrant initiation or incomplete block and was associated with velocity elevation (7.3 vs 2.9 mm s(-1); P = .002) and increased amplitudes beyond a low base value (415 vs 170 μV; P = .002).

conclusionsHigh-resolution mapping revealed new categories of abnormal human slow-wave activity. Abnormalities of slow-wave initiation and conduction occur in gastroparesis, often at normal frequency, which could be missed by tests that lack spatial resolution. Irregular initiation, aberrant conduction, and low amplitude activity could contribute to the pathogenesis of gastroparesis.

Indexed as

Biological ClocksGastric EmptyingAdultBiopsyElectric Stimulation TherapyElectrodiagnosisFemaleGastroparesisHumansInterstitial Cells of CajalMaleMembrane PotentialsMiddle AgedSignal Processing, Computer-AssistedTime Factors

Identifiers

PMID22643349
PMCPMC3429650
OpenAlexW2070564499

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.