ArticleThe Plant cell2012
Integrated systems view on networking by hormones in Arabidopsis immunity reveals multiple crosstalk for cytokinin.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model.Molecular oncology · 2014Trial
- Cytokinin Plays a Multifaceted Role in Ralstonia solanacearum-Triggered Plant Disease Development.Molecular plant pathology · 2024Article
- Salicylic and Jasmonic Acid Synergism during Black Knot Disease Progression in Plums.Plants (Basel, Switzerland) · 2024Article
- Cytokinin drives assembly of the phyllosphere microbiome and promotes disease resistance through structural and chemical cues.The ISME journal · 2022Article
- Two-component signaling system in plants: interaction network and specificity in response to stress and hormones.Plant cell reports · 2021Review
- Genome-wide dynamic network analysis reveals the potential genes for MeJA-induced growth-to-defense transition.BMC plant biology · 2021Article
- Cytokinin Modulates Cellular Trafficking and the Cytoskeleton, Enhancing Defense Responses.Cells · 2021Article
- A genome-wide association study reveals cytokinin as a major component in the root defense responses against Ralstonia solanacearum.Journal of experimental botany · 2021Article
- Modulatory and Toxicological Perspectives on the Effects of the Small Molecule Kinetin.Molecules (Basel, Switzerland) · 2021Article
- Cytokinin Regulation of Source-Sink Relationships in Plant-Pathogen Interactions.Frontiers in plant science · 2021Review
- Cytokinin response induces immunity and fungal pathogen resistance, and modulates trafficking of the PRR LeEIX2 in tomato.Molecular plant pathology · 2020Article
- A Near-Optimal Control Method for Stochastic Boolean Networks.Letters in biomathematics · 2020Article
- Indeterminate Domain Proteins Regulate Rice Defense to Sheath Blight Disease.Rice (New York, N.Y.) · 2020Article
- Role of the Cytokinin-Activated Type-B Response Regulators in Hormone Crosstalk.Plants (Basel, Switzerland) · 2020Review
- Directing Trophic Divergence in Plant-Pathogen Interactions: Antagonistic Phytohormones With NO Doubt?Frontiers in plant science · 2020Review
- Ethylene Response Factor ERF11 ActivatesPlant physiology · 2019Article
- An Arabidopsis TIR-Lectin Two-Domain Protein Confers Defense Properties againstPlant physiology · 2019Article
- Network Modeling Unravels Mechanisms of Crosstalk between Ethylene and Salicylate Signaling in Potato.Plant physiology · 2018Article
- A combined tissue-engineered/in silico signature tool patient stratification in lung cancer.Molecular oncology · 2018Article
- Transcriptome and phytohormone analysis reveals a comprehensive phytohormone and pathogen defence response in pear self-/cross-pollination.Plant cell reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytohormones signal and combine to maintain the physiological equilibrium in the plant. Pathogens enhance host susceptibility by modulating the hormonal balance of the plant cell. Unlike other plant hormones, the detailed role of cytokinin in plant immunity remains to be fully elucidated. Here, extensive data mining, including of pathogenicity factors, host regulatory proteins, enzymes of hormone biosynthesis, and signaling components, established an integrated signaling network of 105 nodes and 163 edges. Dynamic modeling and system analysis identified multiple cytokinin-mediated regulatory interactions in plant disease networks. This includes specific synergism between cytokinin and salicylic acid pathways and previously undiscovered aspects of antagonism between cytokinin and auxin in plant immunity. Predicted interactions and hormonal effects on plant immunity are confirmed in subsequent experiments with Pseudomonas syringae pv tomato DC3000 and Arabidopsis thaliana. Our dynamic simulation is instrumental in predicting system effects of individual components in complex hormone disease networks and synergism or antagonism between pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.