ArticleJournal of controlled release : official journal of the Controlled Release Society2012
Stent elution rate determines drug deposition and receptor-mediated effects.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 121 citations in OpenAlex.
- A Comprehensive Numerical Simulation on the Safety and Efficacy of Circular-Versus Trapezoidal-Shaped Intravascular Drug-Eluting Stents.International journal for numerical methods in biomedical engineering · 2026Article
- A computational model of coronary arteries with in-stent restenosis coupling hemodynamics and pharmacokinetics with growth mechanics.Scientific reports · 2025Article
- Drug coated balloons in percutaneous coronary intervention: how can computational modelling help inform evolving clinical practice?Frontiers in medical technology · 2025Review
- Laplace Transform Based Modeling of Drug Delivery with Reversible Drug Binding in a Multilayer Tissue.Pharmaceutical research · 2024Article
- Endovascular Drug Delivery.Life (Basel, Switzerland) · 2024Review
- Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy.Scientific reports · 2024Article
- Modeling Dual Drug Delivery from Eluting Stents: The Influence of Non-Linear Binding Competition and Non-Uniform Drug Loading.Pharmaceutical research · 2023Article
- Optimization of Initial Drug Distribution in Spherical Capsules for Personalized Release.Pharmaceutical research · 2022Article
- Vascular Lesion-Specific Drug Delivery Systems: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021Review
- An Interactive Pipeline for Quantitative Histopathological Analysis of Spatially Defined Drug Effects in Tumors.Journal of pathology informatics · 2021Article
- A 3D brain unit model to further improve prediction of local drug distribution within the brain.PloS one · 2020Article
- Development of a Bioactive Polymeric Drug Eluting Coronary Stent Coating Using Electrospraying.Annals of biomedical engineering · 2020Article
- Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model.Bulletin of mathematical biology · 2019Article
- The need for mathematical modelling of spatial drug distribution within the brain.Fluids and barriers of the CNS · 2019Review
- Position Paper Computational Cardiology.IEEE journal of biomedical and health informatics · 2019Article
- Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life.Micromachines · 2017Article
- Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Delivery of Antioxidant and Anti-inflammatory Agents for Tissue Engineered Vascular Grafts.Frontiers in pharmacology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a mathematical framework of arterial drug distribution and receptor binding following stent elution. Model predictions that tissue content linearly tracks stent elution rate were validated in porcine coronary artery sirolimus-eluting stents implants. Arterial content varied for stent types, progressively declining from its Day 1 peak and tracking with rate-limiting drug elution--near zero-order release was three-fold more efficient at depositing drug in the stented lesion than near first-order release. In vivo data were consistent with an overabundance of non-specific sirolimus-binding sites relative to the specific receptors and to the delivered dose. The implication is that the persistence time of receptor saturation and effect is more sensitive to duration of elution than to eluted amount. Consequently, the eluted amount should be sufficiently high to saturate receptors at the target lesion, but dose escalation alone is an inefficient strategy for prolonging the duration of sirolimus deposition. Moreover, receptor saturating drug doses are predicted to be most efficacious when eluted from stents in a constant zero order fashion as this maximizes the duration of elution and receptor saturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.