ReviewThe American journal of pathology2012
A historical perspective on sepsis.
Review in The American journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship of serum mannose-binding lectin levels with the development of sepsis: a meta-analysis.Inflammation · 2015Pooled it
- Review
- Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- HSP-Target of Therapeutic Agents in Sepsis Treatment.International journal of molecular sciences · 2019Review
- New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration.Molecular aspects of medicine · 2018Review
- Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis.Cell host & microbe · 2017Article
- Potential Immunotherapeutics for Immunosuppression in Sepsis.Biomolecules & therapeutics · 2017Review
- Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- The immune system's role in sepsis progression, resolution, and long-term outcome.Immunological reviews · 2016Review
- Caspase-8 inhibition represses initial human monocyte activation in septic shock model.Oncotarget · 2016Article
- Sepsis-induced immune dysfunction: can immune therapies reduce mortality?The Journal of clinical investigation · 2016Review
- A Review of GM-CSF Therapy in Sepsis.Medicine · 2015Review
- Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.Journal of leukocyte biology · 2014Article
- PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?Virulence · 2014Review
- Deletion of the gene encoding calcitonin and calcitonin gene-related peptide α does not affect the outcome of severe infection in mice.American journal of respiratory cell and molecular biology · 2013Article
- BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In North America, approximately 700,000 cases of sepsis occur each year, with mortality ranging between 30% and 50%. The American Journal of Pathology has featured numerous articles on the topic, revealing mechanistic insights gleaned from both experimental rodent models and human sepsis. Nonetheless, there remains urgent need to determine the basis for sepsis-related complications and how they can be avoided, as well as how they can be most effectively treated once recognized. This historical perspective reviews what we currently understand about the mechanisms of sepsis, as well as the barriers that remain in our treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.