ArticleToxicological sciences : an official journal of the Society of Toxicology2012
Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Sex dependent intergenerational effects of lead in mouse model.Scientific reports · 2024Article
- Influences of quality of maternal care and environmental enrichment on associative memory function in rats with early life lead exposure.Brain and behavior · 2024Article
- Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits.IBRO neuroscience reports · 2024Article
- Response to "Comment on 'Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?'".Environmental health perspectives · 2024Article
- Early-Life Lead Exposure: Risks and Neurotoxic Consequences.Current medicinal chemistry · 2024Review
- Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?Environmental health perspectives · 2023Article
- Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IPEcotoxicology and environmental safety · 2022Article
- Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.Scientific reports · 2022Article
- Maternal lead exposure induces sex-dependent cerebellar glial alterations and repetitive behaviors.Frontiers in cellular neuroscience · 2022Article
- Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation.Environment international · 2021Article
- Effects of Vitamin C and Magnesium L-threonate Treatment on Learning and Memory in Lead-poisoned Mice.Journal of veterinary research · 2021Article
- Low-level Lead Exposure Impairs Fronto-executive Functions: A Call to Update the DSM-5 with Lead Poisoning as a Neurodevelopmental Disorder.Psychology & neuroscience · 2020Article
- Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder.Journal of neurodevelopmental disorders · 2020Article
- The attention set-shifting test is sensitive for revealing sex-based impairments in executive functions following developmental lead exposure in rats.Behavioural brain research · 2019Article
- Sex-Dependent Impact of Low-Level Lead Exposure during Prenatal Period on Child Psychomotor Functions.International journal of environmental research and public health · 2018Article
- Perinatal PbJournal of biomedical science · 2018Article
- Developmental lead (Pb)-induced deficits in hippocampal protein translation at the synapses are ameliorated by ascorbate supplementation.Neuropsychiatric disease and treatment · 2018Article
- Sex-Dependent Effects of Developmental Lead Exposure on the Brain.Frontiers in genetics · 2018Review
- Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism.Current environmental health reports · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Developmental lead (Pb) exposure has profound effects on cognition and behavior. Much is known about effects of Pb on hippocampal-mediated behaviors, but little is known about the molecular consequences of Pb exposure and the influences of developmental timing of exposure, level of exposure, and sex as effect modifiers of Pb exposure on the brain. The aim of this study was to examine the effects of different levels of Pb exposure (250 and 750 ppm Pb acetate) during perinatal (gestation/lactation) and postnatal (through postnatal day 45) periods on the hippocampal transcriptome in male and female Long Evans rats. Total RNA was extracted from hippocampus from four animals per experimental condition. RNA was hybridized to Affymetrix Rat Gene RNA Arrays using standard methods. Pb exposure per se influenced the expression of 717 transcripts (328 unique annotated genes), with many influenced in a sex-independent manner. Significant differences in gene expression patterns were also influenced by timing and level of exposure, with generally larger effects at the lower level of exposure across all groups. Statistically enriched biological functions included ion binding, regulation of RNA metabolic processes, and positive regulation of macromolecule biosynthetic processes. Processes of regulation of transcription and regulation of gene expression were preferentially enriched in males, regardless of timing or amount of Pb exposure. The effect on transcription factors and the diverse pathways or networks affected by Pb suggest a substantial effect of developmental Pb exposure on plasticity and adaptability, with these effects significantly modified by sex, developmental window of exposure, and level of Pb exposure.
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