ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2012
Furosemide is associated with acute kidney injury in critically ill patients.
Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Diuretics in critically ill patients: a narrative review of their mechanisms and applications.British journal of anaesthesia · 2025Review
- Diuretic treatment using the RenalGuard® system in patients hospitalized due to acute decompensated heart failure and characterization of the profile of patients with good and poor response to treatment - preliminary study.Cardiology journal · 2025Article
- Personalised prediction of maintenance dialysis initiation in patients with chronic kidney disease stages 3-5: a multicentre study using the machine learning approach.BMJ health & care informatics · 2024Article
- A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium.Renal failure · 2022Article
- Loop Diuretics Are Associated with Increased Risk of Hospital-Acquired Acute Kidney Injury in Adult Patients: A Retrospective Study.Journal of clinical medicine · 2022Article
- Risk factors for acute kidney injury after major abdominal surgery in the elderly aged 75 years and above.BMC nephrology · 2022Article
- Loop and thiazide diuretic use and risk of chronic kidney disease progression: a multicentre observational cohort study.BMJ open · 2022Observational
- New Insights Into Diuretic Use to Treat Congestion in the ICU: Beyond Furosemide.Frontiers in nephrology · 2022Review
- 10 myths about frusemide.Intensive care medicine · 2019Article
- Effect of continuous furosemide infusion on outcome of acute kidney injury.Pakistan journal of medical sciences · 2019Article
- Diuretics for All?Turkish journal of anaesthesiology and reanimation · 2017Article
- Fluid overload is an independent risk factor for acute kidney injury in critically Ill patients: results of a cohort study.BMC nephrology · 2017Observational
- Prophylactic furosemide infusion decreasing early major postoperative renal dysfunction in on-pump adult cardiac surgery: a randomized clinical trial.Research and reports in urology · 2017Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) is common in critically ill patients. Diuretics are used without any evidence demonstrating a beneficial effect on renal function. The objective of the present study is to determine the incidence of AKI in an intensive care unit (ICU) and if there is an association between the use of furosemide and the development of AKI. The study involved a hospital cohort in which 344 patients were consecutively enrolled from January 2010 to January 2011. A total of 132 patients (75 females and 57 males, average age 64 years) remained for analysis. Most exclusions were related to ICU discharge in the first 24 h. Laboratory, sociodemographic and clinical data were collected until the development of AKI, medical discharge or patient death. The incidence of AKI was 55% (95%CI = 46-64). The predictors of AKI found by univariate analysis were septic shock: OR = 3.12, 95%CI = 1.36-7.14; use of furosemide: OR = 3.27, 95%CI = 1.57-6.80, and age: OR = 1.02 (95%CI = 1.00-1.04). Analysis of the subgroup of patients with septic shock showed that the odds ratio of furosemide was 5.5 (95%CI = 1.16-26.02) for development of AKI. Age, use of furosemide, and septic shock were predictors of AKI in critically ill patients. Use of furosemide in the subgroup of patients with sepsis/septic shock increased (68.4%) the chance of development of AKI when compared to the sample as a whole (43.9%).
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