ArticleMolecular nutrition & food research2012
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
Article in Molecular nutrition & food research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
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- Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.Molecular carcinogenesis · 2017Article
- Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549.Molecules (Basel, Switzerland) · 2017Article
- Linking Diet to Colorectal Cancer: The Emerging Role of MicroRNA in the Communication between Plant and Animal Kingdoms.Frontiers in microbiology · 2017Review
- Diet and lifestyle factors associated with miRNA expression in colorectal tissue.Pharmacogenomics and personalized medicine · 2017Article
- A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada.Journal of cancer epidemiology · 2017Article
- Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.Cancer letters · 2016Article
- The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer.Nutrients · 2016Review
- Diet, nutrition, and cancer: past, present and future.Nature reviews. Clinical oncology · 2016Review
- The role of microRNA in nutritional control.Journal of internal medicine · 2015Article
- Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention.World journal of gastroenterology · 2014Review
- A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis.Clinical epigenetics · 2012Article
- Mechanistic insights into the role of microRNAs in cancer: influence of nutrient crosstalk.Frontiers in genetics · 2012Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
scopeMicroRNA (miRNA) profiles are altered in chronic conditions such as cardiovascular disease, diabetes, neurological disorders, and cancer. A systems biology approach was used to examine, for the first time, miRNAs altered in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine carcinogen from cooked meat. METHODS AND
resultsAmong the most highly dysregulated miRNAs were those belonging to the let-7 family. Subsequent computational modeling and target validation identified c-Myc and miRNA-binding proteins Lin28A/Lin28B (Lin28) as key players, along with Sox2, Nanog, and Oct-3/4. These targets of altered miRNAs in colon cancers have been implicated in tumor recurrence and reduced patient survival, in addition to their role as pluripotency factors. In parallel with these findings, the tumor-suppressive effects of dietary spinach given postinitiation correlated with elevated levels of let-7 family members and partial normalization of c-myc, Sox2, Nanog, Oct-3/4, HmgA2, Dnmt3b, and P53 expression.
conclusionWe conclude that the let-7/c-Myc/Lin28 axis is dysregulated in heterocyclic amine-induced colon carcinogenesis, and that the tumor suppressive effects of dietary spinach are associated with partial normalization of this pathway.
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