Evidence map›Paper›PMID 22641361›Full record

ReviewNature reviews. Clinical oncology2012

Translational approaches to treatment-induced symptoms in cancer patients.

Robert Dantzer, Mary W Meagher, Charles S Cleeland

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Minocycline for symptom reduction during radiation therapy for head and neck cancer: a randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Trial
  4. Music, heart rate variability, and symptom clusters: a comparative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Trial
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  12. Review
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  16. Observational
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Robert DantzerDepartment of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. rdantzer@mdanderson.org
Mary W Meagher
Charles S Cleeland
The University of Texas MD Anderson Cancer Center · USTexas A&M University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
TARGETING NF-KB ACTIVATION IN REGULATION OF SYMPTOMS IN PATIENTS WITH MULTIPLEP01CA124787 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REUBEN, JAMES MARTIN · 2008 to 2012
$10.6M
Reducing the Symptom Burden Produced by Aggressive Cancer TherapiesR01CA026582 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI CLEELAND, CHARLES S · 1986 to 2013
$7.3M
Neuroimmune Mechanisms of Recovery from Comorbid Depression and Chronic PainR01NS073939 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANTZER, ROBERT, HEIJNEN, COBI J · 2011 to 2020
$4.0M
AIDS, Immune Activation and Mental HealthR01MH079829 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI DANTZER, ROBERT · 2006 to 2010
$1.8M
Impact of social stress-induced cytokines on an animal model of MSR01NS060822 · NINDS · TEXAS A&M UNIVERSITY · PI MEAGHER, MARY W. · 2008 to 2011
$999k
NCI NIH HHS P01 CA124787NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA026582NIMH NIH HHS R01 MH079829NINDS NIH HHS R01 NS060822NINDS NIH HHS R01-NS060822NINDS NIH HHS R01 NS073939
6 · The paper itself

Abstract

Cancer therapy makes patients sick. The therapies that are available to clinicians allow them to successfully control nausea, emesis and pain. However, this is not the case for a number of other symptoms that include fatigue, distractibility, poor memory, and diminished interest in previously pleasurable activities. These symptoms cluster during the course of cancer therapy and impair patient quality of life, limit therapy options and do not always resolve at the cessation of treatment. It is possible to describe the intensity and temporal features of symptoms and assess their relationship with the inflammatory response that is associated with cancer and cancer therapy. At the preclinical level, sophisticated animal models still need to be deployed to study the causal role of inflammation in specific components of cancer-related symptoms. Various approaches can be optimally combined in a translational symptom research pathway to provide a framework for assessing in a systematic manner the neurobehavioral toxicity of existing and newly developed cancer therapies. Ultimately, this knowledge will allow derivation of mechanism-based interventions to prevent or alleviate cancer-related symptoms.

Indexed as

Quality of LifeTranslational Research, BiomedicalAnimalsDepressionFatigueHumansNeoplasmsPain Management

Identifiers

PMID22641361
PMCPMC3412618
OpenAlexW1983608394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.