ArticleNature genetics2012
Exome sequencing and the genetic basis of complex traits.
Abstract read
In one paragraph
Article in Nature genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers, 6 of them syntheses that pooled it.
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0cells of the map it votes in
231citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
231 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Empirically determined baseline masking strategies and other considerations for gene-level burden tests.Nature genetics · 2026Pooled it
- Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease.Molecular psychiatry · 2021Pooled it
- A Systematic Literature Review of Whole Exome and Genome Sequencing Population Studies of Genetic Susceptibility to Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Pooled it
- The influence of rare variants in circulating metabolic biomarkers.PLoS genetics · 2020Pooled it
- Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.Circulation. Cardiovascular genetics · 2016Pooled it
- Meta-analysis of gene-level tests for rare variant association.Nature genetics · 2014Pooled it
- Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage.Proceedings of the National Academy of Sciences of the United States of America · 2016Trial
- Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels.Human genetics · 2015Trial
- Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions.Nature methods · 2026Article
- Exome Sequencing in Adults with Unexplained Liver Disease: Diagnostic Yield and Clinical Impact.Diagnostics (Basel, Switzerland) · 2025Article
- Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location.Scientific reports · 2025Article
- No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks.BMC medicine · 2024Article
- A method to comprehensively identify germline SNVs, INDELs and CNVs from whole exome sequencing data of BRCA1/2 negative breast cancer patients.NAR genomics and bioinformatics · 2024Article
- Germline variation in RASAL2 may predict survival in patients with RAS-activated colorectal cancer.Genes, chromosomes & cancer · 2023Article
- Exome-wide screening identifies novel rare risk variants for bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Article
- A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies.Nature methods · 2022Article
- Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan.BMC biology · 2022Article
- Article
171 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Adam KiezunDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Kiran Garimella
Ron Do
Nathan O Stitziel
Benjamin M Neale
Paul J McLaren
Namrata Gupta
Pamela Sklar
Patrick F Sullivan
Jennifer L Moran
Christina M Hultman
Paul Lichtenstein
Patrik Magnusson
Thomas Lehner
Yin Yao Shugart
Alkes L Price
Paul I W de Bakker
Shaun M Purcell
Shamil R Sunyaev
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MStatistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MAIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1MStatistical and Data Management Center for the AIDS Clinical Trials GroupU01AI068634 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUGHES, MICHAEL DAVID · 2006 to 2010
$71.9MUniversity of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit 2024 SupplementUM1AI069423 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, MINA CHRISTINE HOSSEINIPOUR · 2012 to 2026
$71.8MUCLA AIDS Prevention and Treatment Clinical Trials UnitUM1AI069424 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith S. Currier, RAPHAEL J LANDOVITZ · 2012 to 2026
$51.8MUCSD Department of Medicine HIV/AIDS Clinical Trials UnitUM1AI069432 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TIMOTHY J. WILKIN · 2012 to 2026
$50.4MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MWeill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials UnitUM1AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 2012 to 2026
$44.6MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MCase Clinical Trials Unit: Administrative Supplement NOSI AI-20-031.UM1AI069501 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI George Yendewa · 2012 to 2026
$40.4MThe Johns Hopkins Baltimore-Washington-India Clinical Trials Unit (BWI CTU)UM1AI069465 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Charles W. Flexner, Amita Gupta · 2012 to 2026
$34.1MCIHRNCATS NIH HHS KL2 TR000446NCATS NIH HHS TL1 TR000447NCATS NIH HHS UL1 TR000445NCRR NIH HHS KL2 RR024977NCRR NIH HHS RR024975NCRR NIH HHS TL1 RR024978NCRR NIH HHS UL1 RR024975NHGRI NIH HHS R01 HG005827NHLBI NIH HHS T32 HL007604NHLBI NIH HHS T32-HL07604-25NIAID NIH HHS AI068636NIAID NIH HHS AI069415NIAID NIH HHS AI069419NIAID NIH HHS AI069423NIAID NIH HHS AI069424NIAID NIH HHS AI069428NIAID NIH HHS AI069432NIAID NIH HHS AI069434NIAID NIH HHS AI069450NIAID NIH HHS AI069452NIAID NIH HHS AI069465NIAID NIH HHS AI069471NIAID NIH HHS AI069472NIAID NIH HHS AI069474NIAID NIH HHS AI069477NIAID NIH HHS AI069484NIAID NIH HHS AI069495NIAID NIH HHS AI069501NIAID NIH HHS AI069502NIAID NIH HHS AI069511NIAID NIH HHS AI069513NIAID NIH HHS AI069532NIAID NIH HHS AI069556NIAID NIH HHS AI077505NIAID NIH HHS AI25859NIAID NIH HHS AI27661NIAID NIH HHS AI28568NIAID NIH HHS AI30914NIAID NIH HHS AI34835NIAID NIH HHS AI34853NIAID NIH HHS AI38844NIAID NIH HHS AI46370NIAID NIH HHS AI68634NIAID NIH HHS AI69467NIAID NIH HHS R01 AI028568NIAID NIH HHS R01 AI030914NIAID NIH HHS R01 AI077505NIAID NIH HHS R37 AI028568NIAID NIH HHS U01 AI025859NIAID NIH HHS U01 AI027661NIAID NIH HHS U01 AI032782NIAID NIH HHS U01 AI034835NIAID NIH HHS U01 AI034853NIAID NIH HHS U01 AI038844NIAID NIH HHS U01 AI046370NIAID NIH HHS U01 AI068634NIAID NIH HHS U01 AI068636NIAID NIH HHS U01 AI069415NIAID NIH HHS U01 AI069419NIAID NIH HHS U01 AI069423NIAID NIH HHS U01 AI069424NIAID NIH HHS U01 AI069428NIAID NIH HHS U01 AI069432NIAID NIH HHS U01 AI069434NIAID NIH HHS U01 AI069450NIAID NIH HHS U01 AI069452NIAID NIH HHS U01 AI069465NIAID NIH HHS U01 AI069467NIAID NIH HHS U01 AI069471NIAID NIH HHS U01 AI069472NIAID NIH HHS U01 AI069474NIAID NIH HHS U01 AI069477NIAID NIH HHS U01 AI069484NIAID NIH HHS U01 AI069495NIAID NIH HHS U01 AI069501NIAID NIH HHS U01 AI069502NIAID NIH HHS U01 AI069511NIAID NIH HHS U01 AI069513NIAID NIH HHS U01 AI069532NIAID NIH HHS U01 AI069556NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069415NIAID NIH HHS UM1 AI069419NIAID NIH HHS UM1 AI069423NIAID NIH HHS UM1 AI069424NIAID NIH HHS UM1 AI069428NIAID NIH HHS UM1 AI069432NIAID NIH HHS UM1 AI069434NIAID NIH HHS UM1 AI069450NIAID NIH HHS UM1 AI069452NIAID NIH HHS UM1 AI069465NIAID NIH HHS UM1 AI069467NIAID NIH HHS UM1 AI069471NIAID NIH HHS UM1 AI069472NIAID NIH HHS UM1 AI069474NIAID NIH HHS UM1 AI069477NIAID NIH HHS UM1 AI069484NIAID NIH HHS UM1 AI069495NIAID NIH HHS UM1 AI069501NIAID NIH HHS UM1 AI069502NIAID NIH HHS UM1 AI069511NIAID NIH HHS UM1 AI069513NIAID NIH HHS UM1 AI069532NIAID NIH HHS UM1 AI069556NIMH NIH HHS 1R01MH089208-01NIMH NIH HHS 5R01 MH084676NIMH NIH HHS R01 MH084676NIMH NIH HHS R01 MH089208NIMH NIH HHS R01 MH095034NIMH NIH HHS RC2 MH089905NIMH NIH HHS RC2MH089905PHS HHS AL32782
Abstract
PubMed holds no abstract for this paper.
Indexed as
ExomeGenetic VariationSequence Analysis, DNAGenetic Association StudiesGenetics, PopulationHumansQuality Control
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.