ArticleJournal of proteomics2012
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.
Article in Journal of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- A Snapshot, Using a Multi-Omic Approach, of the Metabolic Cross-Talk and the Dynamics of the Resident Microbiota in Ripening Cheese Inoculated withFoods (Basel, Switzerland) · 2024Article
- Influence ofMetabolites · 2024Article
- Review
- The Exploration of Microbial Natural Products and Metabolic Interaction Guided by Mass Spectrometry Imaging.Bioengineering (Basel, Switzerland) · 2022Review
- High-throughput molecular analyses of microbiomes as a tool to monitor the wellbeing of aquatic environments.Microbial biotechnology · 2021Review
- Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Multiple Streptomyces species with distinct secondary metabolomes have identical 16S rRNA gene sequences.Scientific reports · 2017Article
- Potential of Burkholderia seminalis TC3.4.2R3 as Biocontrol Agent Against Fusarium oxysporum Evaluated by Mass Spectrometry Imaging.Journal of the American Society for Mass Spectrometry · 2017Article
- Clarification of the Antagonistic Effect of the Lipopeptides Produced by Bacillus amyloliquefaciens BPD1 against Pyricularia oryzae via In Situ MALDI-TOF IMS Analysis.Molecules (Basel, Switzerland) · 2016Article
- Analysis of Chemotherapeutic Drug Delivery at the Single Cell Level Using 3D-MSI-TOF-SIMS.Journal of the American Society for Mass Spectrometry · 2016Article
- Profiling the metabolic signals involved in chemical communication between microbes using imaging mass spectrometry.FEMS microbiology reviews · 2016Review
- Review
- Mass spectrometry tools and workflows for revealing microbial chemistry.The Analyst · 2015Review
- Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach.Scientific reports · 2015Article
- Recent trends in non-invasive in situ techniques to monitor bacterial colonies in solid (model) food.Frontiers in microbiology · 2015Article
- Bacterial Colonies in Solid Media and Foods: A Review on Their Growth and Interactions with the Micro-Environment.Frontiers in microbiology · 2015Review
- Improved MALDI-TOF microbial mass spectrometry imaging by application of a dispersed solid matrix.Journal of the American Society for Mass Spectrometry · 2014Article
- Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking.Molecular & cellular proteomics : MCP · 2014Article
- Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Many microbes can be cultured as single-species communities. Often, these colonies are controlled and maintained via the secretion of metabolites. Such metabolites have been an invaluable resource for the discovery of therapeutics (e.g. penicillin, taxol, rapamycin, epothilone). In this article, written for a special issue on imaging mass spectrometry, we show that MALDI-imaging mass spectrometry can be adapted to observe, in a spatial manner, the metabolic exchange patterns of a diverse array of microbes, including thermophilic and mesophilic fungi, cyanobacteria, marine and terrestrial actinobacteria, and pathogenic bacteria. Dependent on media conditions, on average and based on manual analysis, we observed 11.3 molecules associated with each microbial IMS experiment, which was split nearly 50:50 between secreted and colony-associated molecules. The spatial distributions of these metabolic exchange factors are related to the biological and ecological functions of the organisms. This work establishes that MALDI-based IMS can be used as a general tool to study a diverse array of microbes. Furthermore the article forwards the notion of the IMS platform as a window to discover previously unreported molecules by monitoring the metabolic exchange patterns of organisms when grown on agar substrates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.