Evidence map›Paper›PMID 22641138›Full record

ReviewNature reviews. Rheumatology2012

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis.

Paul I Mapp, David A Walsh

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736248 (Super Selective Angiographic Catheterization and Embolization of Genicular Arteries for Treatment of Symptomatic Knee Osteoarthritis), which is not on this map. Cited by 346 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
346citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07736248 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Super Selective Angiographic Catheterization and Embolization of Genicular Arteries for Treatment of Symptomatic Knee Osteoarthritis

TypeinterventionalSponsorAssiut UniversityRan2026 to 2028Enrolled30ConditionsAngioembolization in Knee OsteoarthritisArmsgenicular artery embolization, Calibrated microspheres (100-300 µm), Microcatheter
3 · Its place in the literature

Who cites it

346 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pathogenesis of osteoarthritis, rheumatoid arthritis, and hemophilic arthropathy: The role of angiogenesis.Haemophilia : the official journal of the World Federation of Hemophilia · 2024
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  13. GPNMBCell reports. Medicine · 2026
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286 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paul I MappArthritis Research UK Pain Centre, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK.
David A Walsh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During osteoarthritis (OA), angiogenesis is increased in the synovium, osteophytes and menisci and leads to ossification in osteophytes and the deep layers of articular cartilage. Angiogenic and antiangiogenic factors might both be upregulated in the osteoarthritic joint; however, vascular growth predominates, and the articular cartilage loses its resistance to vascularization. In addition, blood vessel growth is increased at--and disrupts--the osteochondral junction. Angiogenesis in this location is dependent on the creation of channels from subchondral bone spaces into noncalcified articular cartilage. Inflammation drives synovial angiogenesis through macrophage activation. Blood vessel and nerve growth are linked by common pathways that involve the release of proangiogenic factors, such as vascular endothelial growth factor, β-nerve growth factor and neuropeptides. Proangiogenic factors might also stimulate nerve growth, and molecules produced by vascular cells could both stimulate and guide nerve growth. As sensory nerves grow along new blood vessels in osteoarthritic joints, they eventually penetrate noncalcified articular cartilage, osteophytes and the inner regions of menisci. Angiogenesis could, therefore, contribute to structural damage and pain in OA and provide potential targets for new treatments.

Indexed as

Angiogenesis Inducing AgentsAntirheumatic AgentsBlood VesselsCartilage, ArticularChondrocytesHumansNeovascularization, PathologicNerve Growth FactorNeural PathwaysNeuropeptidesOsteoarthritisSynovial MembraneSynovitisVascular Endothelial Growth Factor AAngiogenesis Inducing AgentsAntirheumatic AgentsNerve Growth FactorNeuropeptidesVascular Endothelial Growth Factor A

Identifiers

PMID22641138

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.