ArticleThe pharmacogenomics journal2013
Predicting inhaled corticosteroid response in asthma with two associated SNPs.
Article in The pharmacogenomics journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Circulating MicroRNAs and Treatment Response in Childhood Asthma.American journal of respiratory and critical care medicine · 2020Trial
- Enhancing Asthma Pharmacogenetics Through Subtype-Specific Associations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Article
- Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Assessment of genetic factor and depression interactions for asthma symptom severity in cohorts of childhood and elderly asthmatics.Experimental & molecular medicine · 2018Article
- GLCCI1 rs37973: a potential genetic predictor of therapeutic response to inhaled corticosteroids in Chinese chronic obstructive pulmonary disease patients.Scientific reports · 2017Article
- Whole genome prediction and heritability of childhood asthma phenotypes.Immunity, inflammation and disease · 2016Article
- A Mutagenic Primer Assay for Genotyping of the CRHR1 Gene Rare Variant rs1876828 (A/G) in Asians: A Cost-Effective SNP Typing.Journal of clinical laboratory analysis · 2016Article
- CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids.Immunity, inflammation and disease · 2015Article
- Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving.Pharmacogenomics · 2015Article
- CGBayesNets: conditional Gaussian Bayesian network learning and inference with mixed discrete and continuous data.PLoS computational biology · 2014Article
- Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.The Journal of allergy and clinical immunology · 2014Article
- Asthma treatment outcome in adults is associated with rs9910408 in TBX21 gene.Scientific reports · 2013Article
- Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Inhaled corticosteroids (ICS) are the most commonly used controller medications prescribed for asthma. Two single-nucleotide polymorphisms (SNPs), rs1876828 in corticotrophin releasing hormone receptor 1 and rs37973 in GLCCI1, have previously been associated with corticosteroid efficacy. We studied data from four existing clinical trials of asthmatics, who received ICS and had lung function measured by forced expiratory volume in 1 s (FEV1) before and after the period of such treatment. We combined the two SNPs rs37973 and rs1876828 into a predictive test of FEV1 change using a Bayesian model, which identified patients with good or poor steroid response (highest or lowest quartile, respectively) with predictive performance of 65.7% (P=0.039 vs random) area under the receiver-operator characteristic curve in the training population and 65.9% (P=0.025 vs random) in the test population. These findings show that two genetic variants can be combined into a predictive test that achieves similar accuracy and superior replicability compared with single SNP predictors.
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Registered trials
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