ArticleDiagnostic pathology2012
The clinicopathologic association of c-MET overexpression in Iranian gastric carcinomas; an immunohistochemical study of tissue microarrays.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- The Significance of MET Expression and Strategies of Targeting MET Treatment in Advanced Gastric Cancer.Frontiers in oncology · 2021Article
- Precision medicine in gastric cancer.World journal of gastrointestinal oncology · 2019Review
- Human epidermal growth factor receptor 2-, epidermal growth factor receptor-, and mesenchymal epithelial transition factor-positive sites of gastric cancer using surgical samples.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.Clinical and experimental medicine · 2017Article
- Clinicopathological Significance and Diagnostic Accuracy of c-MET Expression by Immunohistochemistry in Gastric Cancer: A Meta-Analysis.Journal of gastric cancer · 2016Article
- Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation.Oncotarget · 2016Article
- A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study.OncoTargets and therapy · 2016Article
- Prognostic impact of HER2, EGFR, and c-MET status on overall survival of advanced gastric cancer patients.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Targeted therapy for advanced gastric cancer: A review of current status and future prospects.World journal of gastrointestinal oncology · 2015Review
- c-MET expression in colorectal adenomas and primary carcinomas with its corresponding metastases.Journal of gastrointestinal oncology · 2015Article
- Clinical significance of MET in gastric cancer.World journal of gastrointestinal oncology · 2015Review
- MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway.PloS one · 2015Article
- Prognostic significance of the co-expression of nucleophosmin and trefoil factor 3 in postoperative gastric cancer patients.Molecular and clinical oncology · 2014Article
- HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development.Oncotarget · 2014Review
- Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer.Diagnostic pathology · 2014Article
- Expression characteristics of CDC20 in gastric cancer and its correlation with poor prognosis.International journal of clinical and experimental pathology · 2014Article
- The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer.Diagnostic pathology · 2013Article
- Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.Diagnostic pathology · 2013Article
- Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients.Diagnostic pathology · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundc-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric cancer of Iranian population using tissue microarray.
methodsIn a cross sectional study, representative paraffin blocks of 130 patients with gastric carcinoma treated by curative gastrectomy during a 2 years period of 2008-2009 in two university hospitals in Tehran-Iran were collected in tissue microarray and c-MET expression was studied by immunohistochemical staining.
resultsFinally 124 cases were evaluated, constituted of 99 male and 25 female with the average age of 61.5 years. In 71% (88/124) of tumors, c-MET high expression was found. c-MET high expression was more associated with intestinal than diffuse tumor type (P = 0.04), deeper tumor invasion, pT3 and pT4 versus pT1 and pT2 (P = 0.014), neural invasion (P = 0.002) and advanced TNM staging, stage 3 and 4 versus stage 1 and2 (P = 0.044). The c-MET high expression was not associated with age, sex, tumor location, differentiation grade and distant metastasis, but relative associations with lymph node metastasis (P = 0.065) and vascular invasion (P = 0.078) were observed.
conclusionsc-MET oncogene protein was frequently overexpressed in Iranian gastric carcinomas and it was related to clinicopathological characteristics such as tumor type, depth of invasion, neural invasion and TNM staging. It can also support the idea that c-MET is a potential marker for target therapy in Iranian gastric cancer. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9744598757151429.
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