ArticleBehavioral and brain functions : BBF2012
The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD.
Article in Behavioral and brain functions : BBF, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Gene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- The distribution of parent-reported attention-deficit/hyperactivity disorder and subclinical autistic traits in children with and without an ADHD diagnosis.JCPP advances · 2024Article
- Proline-rich polypeptides (ColostrininFood science & nutrition · 2023Article
- Article
- Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice.Behavioural brain research · 2018Article
- Pharmacogenetic guidance: individualized medicine promotes enhanced pain outcomes.Journal of pain research · 2018Article
- A decade of contributions to understanding and ameliorating attention deficit-hyperactivity disorder.Behavioral and brain functions : BBF · 2016Review
- Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.Genes, brain, and behavior · 2016Review
- Influence of the COMT val(108/158)met polymorphism on continuous performance task indices.Neuropsychologia · 2014Article
- The association between the catechol-O-methyltransferase Val108/158Met polymorphism and hyperactive-impulsive and inattentive symptoms in youth.Psychopharmacology · 2013Article
- Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder.BMC research notes · 2013Article
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Authors and funding
10 authors.
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Abstract
backgroundThis study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD.
methodsOne hundred and eighteen children with ADHD performed three working memory measures taken from the CANTAB battery (Spatial Span, Delayed-match-to-sample, and Spatial Working Memory). Associations between performance on working memory measures and allelic variation in catecholamine genes (including those for the noradrenaline transporter [NET1], the dopamine D4 and D2 receptor genes [DRD4; DRD2], the gene encoding dopamine beta hydroxylase [DBH] and catechol-O-methyl transferase [COMT]) were investigated using regression models that controlled for age, IQ, gender and medication status on the day of test.
resultsSignificant associations were found between performance on the delayed-match-to-sample task and COMT genotype. More specifically, val/val homozygotes produced significantly more errors than did children who carried a least one met allele. There were no further associations between allelic variants and performance across the other working memory tasks.
conclusionsThe working memory measures employed in the present study differed in the degree to which accurate task performance depended upon either the dynamic updating and/or manipulation of items in working memory, as in the spatial span and spatial working memory tasks, or upon the stable maintenance of representations, as in the delay-match-to-sample task. The results are interpreted as evidence of a relationship between tonic dopamine levels associated with the met COMT allele and the maintenance of stable working memory representations required to perform the delayed-match-to-sample-task.
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