Evidence map›Paper›PMID 22640368›Full record

ArticleCellular microbiology2012

Host-microbe interactions that shape the pathogenesis of Acinetobacter baumannii infection.

Brittany L Mortensen, Eric P Skaar

Open access · bronzeAbstract read
In one paragraph

Article in Cellular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Comparative analysis ofFrontiers in microbiology · 2025
    Article
  3. Article
  4. Article
  5. Interactions between host epithelial cells andEmerging microbes & infections · 2022
    Article
  6. Article
  7. Article
  8. Dissemination of novel TnMicrobial genomics · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Host Innate Immune Responses toFrontiers in cellular and infection microbiology · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. COLFrontiers in microbiology · 2019
    Article
  19. Whole-Genome Sequences of FiveFrontiers in microbiology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Brittany L MortensenDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Eric P Skaar
Vanderbilt University · US

Funding

Pathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9M
Mechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6M
The Impact of Calprotectin-Mediated Metal Chelation on Host-Pathogen InteractionsR56AI091771 · NIAID · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J., SKAAR, ERIC P · 2011 to 2011
$390k
ACF HHS AF073843NIAID NIH HHS AI069233NIAID NIH HHS AI091771NIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI073843NIAID NIH HHS R56 AI091771
6 · The paper itself

Abstract

Acinetobacter baumannii is an opportunistic pathogen that has emerged as a prevalent source of nosocomial infections, most frequently causing ventilator-associated pneumonia. The emergence of pan-drug resistant strains magnifies the problem by reducing viable treatment options and effectively increasing the mortality rate associated with Acinetobacter infections. In light of this rising threat, research on A. baumannii epidemiology, antibiotic resistance, and pathogenesis is accelerating. The recent development of both in vitro and in vivo models has enabled studies probing the host-Acinetobacter interface. Bacterial genetic screens and comparative genomic studies have led to the identification of several A. baumannii virulence factors. Additionally, investigations into host defence mechanisms using animal models or cell culture have provided insight into the innate immune response to infection. This review highlights some of the key attributes of A. baumannii virulence with an emphasis on bacterial interactions with the innate immune system.

Indexed as

Host-Pathogen InteractionsAcinetobacter baumanniiAcinetobacter InfectionsAnimalsDisease Models, AnimalGene Expression ProfilingHumansImmunity, InnateVirulence FactorsVirulence Factors

Identifiers

PMID22640368
PMCPMC3781221
OpenAlexW1502121327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.