ArticleACS macro letters2012
Guanidine-Containing Methacrylamide (Co)polymers via aRAFT: Toward a Cell Penetrating Peptide Mimic().
Article in ACS macro letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 81 citations in OpenAlex.
- Aqueous Carbon Capture Using Guanidinium-Functionalized Hollow Fiber Sorbent Contactors.JACS Au · 2026Article
- Cyclic Methacrylate Tetrahydropyrimidinones: Synthesis, Properties, (Co)Polymerization.Polymers · 2021Article
- A Guanidine-Based Superbase as Efficient Chemiluminescence Booster.Scientific reports · 2019Article
- Protein Transduction Domain Mimic (PTDM) Self-Assembly?Polymers · 2018Article
- Guanidinium-Functionalized Interpolyelectrolyte Complexes Enabling RNAi in Resistant Insect Pests.Biomacromolecules · 2018Article
- Increased RNAi Efficacy inFrontiers in physiology · 2018Article
- ROMP- and RAFT-Based Guanidinium-Containing Polymers as Scaffolds for Protein Mimic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Block ionomer complexes consisting of siRNA andPolymer chemistry · 2016Article
- Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization.Biomacromolecules · 2016Article
- Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery.Journal of the American Chemical Society · 2016Article
- Antimicrobial Peptide Mimicking Primary Amine and Guanidine Containing Methacrylamide Copolymers Prepared by Raft Polymerization.Biomacromolecules · 2015Article
- Development of Guanidinium-Rich Protein Mimics for Efficient siRNA Delivery into Human T Cells.Biomacromolecules · 2015Article
- Development of protein mimics for intracellular delivery.Biopolymers · 2015Review
- Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes.Polymer chemistry · 2015Article
- Engineering biodegradable and multifunctional peptide-based polymers for gene delivery.Journal of biological engineering · 2013Article
- Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery.Biomaterials science · 2013Article
- Substrate-initiated synthesis of cell-penetrating poly(disulfide)s.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We report the synthesis and controlled radical homo- and block copolymerization of 3-guanidinopropyl methacrylamide (GPMA) utilizing aqueous reversible addition-fragmentation chain transfer (aRAFT) polymerization. The resulting homopolymer and block copolymer with N-(2-hydroxypropyl) methacrylamide (HPMA) were prepared to mimic the behavior of cell penetrating peptides (CPPs) and poly(arginine) (> 6 units) which have been shown to cross cell membranes. The homopolymerization mediated by 4-cyano-4-(ethylsulfanylthiocarbonylsulfanyl)pentanoic acid (CEP) in aqueous buffer exhibited pseudo-first-order kinetics and linear growth of molecular weight with conversion. Retention of the "living" thiocarbonylthio ω-end-group was demonstrated through successful chain extension of the GPMA macroCTA yielding GPMA(37)-b-GPMA(61) (M(w)/M(n) =1.05). Block copolymers of GPMA with the non-immunogenic, biocompatible HPMA were synthesized yielding HPMA(271)-b-GPMA(13) (M(w)/M(n) = 1.15). Notably, intracellular uptake was confirmed by fluorescence microscopy, confocal laser scanning microscopy, and flow cytometry experiments after 2.5 h incubation with KB cells at 4 °C and at 37 °C utilizing FITC-labeled, GPMA-containing copolymers. The observed facility of cellular uptake and the structural control afforded by aRAFT polymerization suggest significant potential for these synthetic (co)polymers as drug delivery vehicles in targeted therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.