ArticleFrontiers in plant science2012
Escape from preferential retention following repeated whole genome duplications in plants.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of genome duplication on secondary metabolite composition in non-cultivated species: a systematic meta-analysis.Annals of botany · 2020Pooled it
- Evolutionary causes and consequences of gene duplication.Nature reviews. Genetics · 2026Review
- A sorghum-anchored pan-grass syntenic gene set in grasses.NAR genomics and bioinformatics · 2026Article
- Genome-Wide Identification of the Sulfate Transporter Gene Family Reveals ThatAntioxidants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification and Expression Analysis of the Aux/IAA Gene Family in Lettuce (International journal of molecular sciences · 2025Article
- Review
- Article
- Identification and functional annotation of long intergenic non-coding RNAs in Brassicaceae.The Plant cell · 2022Article
- The multiple fates of gene duplications: Deletion, hypofunctionalization, subfunctionalization, neofunctionalization, dosage balance constraints, and neutral variation.The Plant cell · 2022Article
- A Population-Genetic Lens into the Process of Gene Loss Following Whole-Genome Duplication.Molecular biology and evolution · 2022Article
- Gene Balance Predicts Transcriptional Responses Immediately Following Ploidy Change inThe Plant cell · 2020Article
- Evolution of the RNAPlant physiology · 2020Article
- Expression Partitioning of Duplicate Genes at Single Cell Resolution inFrontiers in genetics · 2020Article
- Genome-wide analysis of cotton C2H2-zinc finger transcription factor family and their expression analysis during fiber development.BMC plant biology · 2019Article
- Reciprocally Retained Genes in the Angiosperm Lineage Show the Hallmarks of Dosage Balance Sensitivity.The Plant cell · 2017Article
- Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogentic Tree of the Paniceae Grasses.Scientific reports · 2017Article
- Long-read sequencing uncovers the adaptive topography of a carnivorous plant genome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Statistical analysis of fractionation resistance by functional category and expression.BMC genomics · 2017Article
- Evolution of Gene Duplication in Plants.Plant physiology · 2016Review
- Understanding Brassicaceae evolution through ancestral genome reconstruction.Genome biology · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The well supported gene dosage hypothesis predicts that genes encoding proteins engaged in dose-sensitive interactions cannot be reduced back to single copies once all interacting partners are simultaneously duplicated in a whole genome duplication. The genomes of extant flowering plants are the result of many sequential rounds of whole genome duplication, yet the fraction of genomes devoted to encoding complex molecular machines does not increase as fast as expected through multiple rounds of whole genome duplications. Using parallel interspecies genomic comparisons in the grasses and crucifers, we demonstrate that genes retained as duplicates following a whole genome duplication have only a 50% chance of being retained as duplicates in a second whole genome duplication. Genes which fractionated to a single copy following a second whole genome duplication tend to be the member of a gene pair with less complex promoters, lower levels of expression, and to be under lower levels of purifying selection. We suggest the copy with lower levels of expression and less purifying selection contributes less to effective gene-product dosage and therefore is under less dosage constraint in future whole genome duplications, providing an explanation for why flowering plant genomes are not overrun with subunits of large dose-sensitive protein complexes.
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