ArticleFrontiers in plant science2012
An expanding role for purine uptake permease-like transporters in plant secondary metabolism.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- A versatile yeast platform for N-demethylation of therapeutic alkaloids.Journal of biological engineering · 2026Article
- Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters.The Plant journal : for cell and molecular biology · 2026Review
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- The leaf idioblastome of the medicinal plant Catharanthus roseus is associated with stress resistance and alkaloid metabolism.Journal of experimental botany · 2024Article
- SWEET11b transports both sugar and cytokinin in developing barley grains.The Plant cell · 2023Article
- Terpenoid Transport in Plants: How Far from the Final Picture?Plants (Basel, Switzerland) · 2023Review
- Functional identification of purine permeases reveals their roles in caffeine transport in tea plants (Frontiers in plant science · 2022Article
- Transport engineering for improving the production and secretion of valuable alkaloids inMetabolic engineering communications · 2021Article
- An ATP-Binding Cassette Transporter, LaABCB11, Contributes to Alkaloid Transport inInternational journal of molecular sciences · 2021Article
- Membrane transporters: the key drivers of transport of secondary metabolites in plants.Plant cell reports · 2021Review
- Plant Secondary Metabolite Transporters: Diversity, Functionality, and Their Modulation.Frontiers in plant science · 2021Review
- Plant Membrane Transport Research in the Post-genomic Era.Plant communications · 2020Review
- Cytokinins in Dictyostelia - A Unique Model for Studying the Functions of Signaling Agents From Species to Kingdoms.Frontiers in cell and developmental biology · 2020Review
- Purine Permease-Type Benzylisoquinoline Alkaloid Transporters in Opium Poppy.Plant physiology · 2019Article
- The solute transport and binding profile of a novel nucleobase cation symporter 2 from the honeybee pathogenFEBS open bio · 2018Article
- Cytokinins on the Move.Frontiers in plant science · 2017Review
- The solute specificity profiles of nucleobase cation symporter 1 (NCS1) from Zea mays and Setaria viridis illustrate functional flexibility.Protoplasma · 2016Article
- Genetic Factors for Enhancement of Nicotine Levels in Cultivated Tobacco.Scientific reports · 2015Article
- Nucleobase and nucleoside transport and integration into plant metabolism.Frontiers in plant science · 2014Review
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the past decade, our understanding of the plant purine uptake permease (PUP) transporter family was primarily oriented on purine nucleobase substrates and their tissue-specific expression patterns in Arabidopsis. However, a tobacco PUP-like homolog demonstrating nicotine uptake permease activity was recently shown to affect both nicotine metabolism and root cell growth. These new findings expand the physiological role for PUP-like transporters to include plant secondary metabolism. Molecular evolution analyses of PUP-like transporters indicate they are distinct group within an ancient super family of drug and metabolite transporters (DMTs). The PUP-like family originated during terrestrial plant evolution sometime between the bryophytes and the lycophytes. A phylogenetic analysis indicates that the PUP-like transporters were likely derived from a pre-existing nucleotide-sugar transporter family within the DMT super family. Within the lycophyte Selaginella, there are three paralogous groups of PUP-like transporters. One of the three PUP-like paralogous groups showed an extensive pattern of gene duplication and diversification within the angiosperm lineage, whereas the more ancestral PUP-like paralogous groups did not. Biochemical characterization of four closely related PUP-like paralogs together with model-based phylogenetic analyses indicate both subfunctionalization and neofunctionalization during the molecular evolution of angiosperm PUP-like transporters. These findings suggest that members of the PUP-like family of DMT transporters are likely involved in diverse primary and secondary plant metabolic pathways.
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