ArticleFrontiers in plant science2011
Mining disease-resistance genes in roses: functional and molecular characterization of the rdr1 locus.
Article in Frontiers in plant science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Genome-wide detection of selection signatures in roses.BMC plant biology · 2026Article
- Engineering resilient roses: molecular insights into biotic and abiotic stress adaptation.Horticulture research · 2026Article
- Review
- Morphological and hormonal diversity in rose (Rosa hybrida L.) and potato (Solanum tuberosum L.) Ri genotypes: A comparative study.PloS one · 2026Article
- Recent Progress in Enhancing Fungal Disease Resistance in Ornamental Plants.International journal of molecular sciences · 2021Review
- Characterization of black spot resistance in diploid roses with QTL detection, meta-analysis and candidate-gene identification.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Identification of a polymorphism within the Rosa multiflora muRdr1A gene linked to resistance to multiple races of Diplocarpon rosae W. in tetraploid garden roses (Rosa × hybrida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Article
- Interaction of roses with a biotrophic and a hemibiotrophic leaf pathogen leads to differences in defense transcriptome activation.Plant molecular biology · 2019Article
- IdentifyingFrontiers in plant science · 2019Article
- In the name of the rose: a roadmap for rose research in the genome era.Horticulture research · 2019Article
- Insight on Rosaceae Family with Genome Sequencing and Functional Genomics Perspective.BioMed research international · 2019Review
- The TNL gene Rdr1 confers broad-spectrum resistance to Diplocarpon rosae.Molecular plant pathology · 2018Article
- Genome structure of Rosa multiflora, a wild ancestor of cultivated roses.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- A draft genome sequence of the rose black spot fungus Diplocarpon rosae reveals a high degree of genome duplication.PloS one · 2017Article
- Evolution of the Rdr1 TNL-cluster in roses and other Rosaceous species.BMC genomics · 2012Article
- Isolation, Molecular Characterization, and Mapping of Four Rose MLO Orthologs.Frontiers in plant science · 2012Article
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8 authors.
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Abstract
The interaction of roses with the leaf spot pathogen Diplocarpon rosae (the cause of black spot on roses) is an interesting pathosystem because it involves a long-lived woody perennial, with life history traits very different from most model plants, and a hemibiotrophic pathogen with moderate levels of gene flow. Here we present data on the molecular structure of the first monogenic dominant resistance gene from roses, Rdr1, directed against one isolate of D. rosae. Complete sequencing of the locus carrying the Rdr1 gene resulted in a sequence of 265,477 bp with a cluster of nine highly related TIR-NBS-LRR (TNL) candidate genes. After sequencing revealed candidate genes for Rdr1, we implemented a gene expression analysis and selected five genes out of the nine TNLs. We then silenced the whole TNL gene family using RNAi (Rdr1-RNAi) constructed from the most conserved sequence region and demonstrated a loss of resistance in the normally resistant genotype. To identify the functional TNL gene, we further screened the five TNL candidate genes with a transient leaf infiltration assay. The transient expression assay indicated a single TNL gene (muRdr1H), partially restoring resistance in the susceptible genotype. Rdr1 was found to localize within the muRdr1 gene family; the genes within this locus contain characteristic motifs of active TNL genes and belong to a young cluster of R genes. The transient leaf assay can be used to further analyze the rose black spot interaction and its evolution, extending the analyses to additional R genes and to additional pathogenic types of the pathogen.
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