ArticleNeoReviews2011
Innate Immunity in the Small Intestine of the Preterm Infant.
Article in NeoReviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03235635 (Metagenome Analysis of Intestinal Microbiome in Mortality and Morbidity of Preterm Infants), which is not on this map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metagenome Analysis of Intestinal Microbiome in Mortality and Morbidity of Preterm Infants
Who cites it
46 citing papers in PubMed, 68 citations in OpenAlex.
- Pathogenesis of necrotizing enterocolitis: mechanisms and mediators.World journal of pediatric surgery · 2026Review
- A neonatal mouse model of meconium peritonitis generated using human meconium slurry.Pediatric research · 2025Article
- Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota.Nutrients · 2024Review
- The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut-Brain Axis Development and Life-Long Health Outcomes.Microorganisms · 2023Review
- New insights into the pathogenesis of necrotizing enterocolitis and the dawn of potential therapeutics.Seminars in pediatric surgery · 2023Review
- Association of anemia and platelet activation with necrotizing enterocolitis with or without sepsis among low birth weight neonates: a case-control study.Frontiers in pediatrics · 2023Article
- Antimicrobial Peptides in Early-Life Host Defense, Perinatal Infections, and Necrotizing Enterocolitis-An Update.Journal of clinical medicine · 2022Review
- Intestinal epithelium in early life.Mucosal immunology · 2022Review
- Hyaluronic Acid 35 kDa Protects against a Hyperosmotic, Formula Feeding Model of Necrotizing Enterocolitis.Nutrients · 2022Article
- Anti-RBD IgA and IgG Response and Transmission in Breast Milk of Anti-SARS-CoV-2 Vaccinated Mothers.Pathogens (Basel, Switzerland) · 2022Article
- Heat Stress Modulates a Placental Immune Response Associated With Alterations in the Development of the Fetal Intestine and Its Innate Immune System in Late Pregnant Mouse.Frontiers in physiology · 2022Article
- Article
- Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity.International journal of molecular sciences · 2021Article
- Prenatal stress increases IgA coating of offspring microbiota and exacerbates necrotizing enterocolitis-like injury in a sex-dependent manner.Brain, behavior, and immunity · 2020Article
- Predicted Metabolic Pathway Distributions in Stool Bacteria in Very-Low-Birth-Weight Infants: Potential Relationships with NICU Faltered Growth.Nutrients · 2020Article
- IL-17-producing γδ T cells protect against Clostridium difficile infection.The Journal of clinical investigation · 2020Article
- Preterm neonatal immunology at the intestinal interface.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- Bioactive Factors in Human Breast Milk Attenuate Intestinal Inflammation during Early Life.Nutrients · 2020Review
- The Paneth Cell: The Curator and Defender of the Immature Small Intestine.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The gastrointestinal tract comprises the largest surface area of the human body. This area is constantly exposed to myriad antigens as well as the large number of bacteria that coexist in the intestinal lumen. To protect against this exposure and help distinguish "self " from "foreign," the intestinal tract has evolved a sophisticated barrier defense system that includes both innate and adaptive immune systems. However, infants who are born preterm do not have the benefit of an adequate immune response and, therefore, are more susceptible to bacterial injury, inflammation, and intestinal diseases such as necrotizing enterocolitis. In this review, we discuss the components of innate immunity that help to protect the small intestine as well as current knowledge about the role of these components in the pathophysiology of necrotizing enterocolitis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.