Evidence map›Paper›PMID 22639388›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012

ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos.

K J Fishwick, E Kim, M E Bronner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

K J FishwickDivision of Biology, California Institute of Technology, Pasadena, California, USA.
E Kim
M E Bronner
California Institute of Technology · US

Funding

Center for in Toto Genomic Analysis of Vertebrate DevelopmentP50HG004071 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FRASER, SCOTT E · 2006 to 2011
$18.4M
Ectodermal Placode Development into Sensory StructuresR01DE016459 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2004 to 2014
$3.8M
NHGRI NIH HHS HG004071NHGRI NIH HHS P50 HG004071NIDCR NIH HHS R01 DE016459
6 · The paper itself

Abstract

backgroundThe neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families.

resultsHere we identify a novel chick gene with close homology to double-stranded RNA-binding protein Interleukin enhancer binding factor 3 (ILF-3) in other species. Our results show that chick Ilf-3 is required for proper expression of the transcription factor, Zic-1, at the neural plate border.

conclusionWe have identified a novel chick gene and show it has a role in the correct specification of Zic-1 at the neural plate border.

Indexed as

AnimalsChick EmbryoChickensGene Expression Regulation, DevelopmentalNeural CrestNeural PlateNuclear Factor 90 ProteinsTranscription FactorsNuclear Factor 90 ProteinsTranscription Factors

Identifiers

PMID22639388
PMCPMC3399927
OpenAlexW2081452921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.