ArticleJournal of cardiovascular translational research2012
Enhanced endothelialization of a new stent polymer through surface enhancement and incorporation of growth factor-delivering microparticles.
Article in Journal of cardiovascular translational research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Targeted chemotherapy via HER2-based chimeric antigen receptor (CAR) engineered T-cell membrane coated polymeric nanoparticles.Bioactive materials · 2024Article
- Covalent coating strategy for enhancing the biocompatibility and hemocompatibility of blood-contacting medical materials.Pharmaceutical science advances · 2023Review
- Accelerated Endothelialization of Nanofibrous Scaffolds for Biomimetic Cardiovascular Implants.Materials (Basel, Switzerland) · 2022Article
- The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents.Micromachines · 2021Review
- Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- 3D-Printed PCL/PLA Composite Stents: Towards a New Solution to Cardiovascular Problems.Materials (Basel, Switzerland) · 2018Article
- Citrate chemistry and biology for biomaterials design.Biomaterials · 2018Review
- Shape Memory Polymers Containing Higher Acrylate Content Display Increased Endothelial Cell Attachment.Polymers · 2017Article
- Dual-Drug Containing Core-Shell Nanoparticles for Lung Cancer Therapy.Scientific reports · 2017Article
- Cardiovascular Bio-Engineering: Current State of the Art.Journal of cardiovascular translational research · 2017Review
- Experimental study of ASCs combined with POC-PLA patch for the reconstruction of full-thickness chest wall defects.PloS one · 2017Article
- Direct Adsorption of Anti-CD34 Antibodies on the Nano-Porous Stent Surface to Enhance Endothelialization.Acta Cardiologica Sinica · 2016Article
- Accelerating in situ endothelialisation of cardiovascular bypass grafts.International journal of molecular sciences · 2014Review
- Multi-ligand poly(L-lactic-co-glycolic acid) nanoparticles inhibit activation of endothelial cells.Journal of cardiovascular translational research · 2013Article
- Enhanced human endothelial progenitor cell adhesion and differentiation by a bioinspired multifunctional nanomatrix.Tissue engineering. Part C, Methods · 2013Article
- Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In this study, we sought to develop strategies for improved endothelialization of a new polymer coating for vascular stents. Surface enhancement of the new poly-1,8-octanediol-co-citric acid (POC) polymer was achieved through conjugation of anti-CD34 antibody and incorporation of vascular endothelial growth factor and basic fibroblast growth factor-containing poly-lactic-co-glycolic acid microparticles to improve capture and proliferation of endothelial progenitor cells (EPC) and compared to untreated POC and poly-L-lactic acid (PLLA) polymer. Our results indicate that compared to PLLA, POC coating was more hemocompatible, with less platelet activation (p = 0.01), thrombogenicity (p < 0.05 for 20 and 30 min clot formation), and inflammatory response (IL-1β release, p = 0.0009; TNF-α release, p = 0.004). EPC adhesion and proliferation on POC were significantly improved with surface enhancement and microparticle incorporation compared to untreated POC (p = 0.006) and PLLA (p = 0.003). These results suggest a new strategy for enhancing endothelialization of polymeric coatings of vascular prostheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.