ReviewJournal of cardiovascular translational research2012
In vitro uses of human pluripotent stem cell-derived cardiomyocytes.
Review in Journal of cardiovascular translational research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Elucidating effects of environmental exposure using human-induced pluripotent stem cell disease modeling.EMBO molecular medicine · 2022Review
- Paracrine IGF-1 Activates SOD2 Expression and Regulates ROS/p53 Axis in the Treatment of Cardiac Damage in D-Galactose-Induced Aging Rats after Receiving Mesenchymal Stem Cells.Journal of clinical medicine · 2022Article
- Stem Cells: The Game Changers of Human Cardiac Disease Modelling and Regenerative Medicine.International journal of molecular sciences · 2019Review
- Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium.Stem cell reports · 2017Article
- Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine.Physiological reviews · 2016Review
- Evolution of strategies to improve preclinical cardiac safety testing.Nature reviews. Drug discovery · 2016Review
- Guidelines for translational research in heart failure.Journal of cardiovascular translational research · 2015Article
- Human stem cells for modeling heart disease and for drug discovery.Science translational medicine · 2014Review
- Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes.European heart journal · 2014Article
- Cardiac stem cell biology: glimpse of the past, present, and future.Circulation research · 2014Review
- Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes.Stem cells (Dayton, Ohio) · 2013Review
- Direct reprogramming of mouse fibroblasts into cardiac myocytes.Journal of cardiovascular translational research · 2013Review
- Embryonic template-based generation and purification of pluripotent stem cell-derived cardiomyocytes for heart repair.Journal of cardiovascular translational research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Functional cardiomyocytes can be efficiently derived from human pluripotent stem cells (hPSCs), which collectively include embryonic and induced pluripotent stem cells. This cellular platform presents exciting new opportunities for development of pharmacologically relevant in vitro screens to detect cardiotoxicity, validate novel drug candidates in preclinical trials and understand complex congenital cardiovascular disorders, to advance current clinical therapies. Here, we discuss the progress and impediments the field has faced in using hPSC-derived cardiomyocytes for these in vitro applications, and highlight that rigorous protocol optimisation and standardisation, scalability and automation are remaining obstacles for the generation of pure, mature and clinically relevant hPSC cardiomyocytes.
Indexed as
Identifiers
22639342What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.